Reactome Pathway Database

Schema > Reaction > Entries

Dissociation of oncogenic RAS:RAF complex Show undefined attributes

authored

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

category dissociation

compartment

[Compartment:70101] cytosol

created [InstanceEdit:6803232] Rothfels, Karen, 2015年10月05日

crossReference

dbId 6803233

disease

displayName Dissociation of oncogenic RAS:RAF complex

edited

[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日

entityFunctionalStatus

[EntityFunctionalStatus:6803231] gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

eventOf

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens

input

[Complex:R-HSA-6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Dissociation of oncogenic RAS:RAF complex

normalReaction [Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex

output

precedingEvent

[Reaction:R-HSA-6802922] Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS - Homo sapiens

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-6803233

summation

[Summation:6803224] After phosphorylation by MAP2Ks, the scaffolded kinase compl...

Referrals

(hasEvent)

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants

© 2025 Reactome

Cite Us!