Reactome Pathway Database

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gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] Show undefined attributes

created [InstanceEdit:6803232] Rothfels, Karen, 2015年10月05日

dbId 6803231

diseaseEntity [Complex:R-HSA-6802672] mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

displayName gain_of_function of mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]

functionalStatus

[FunctionalStatus:2362351] gain_of_function via non_conservative_missense_variant

modified [InstanceEdit:9631717] Wu, G, 2018年12月12日

normalEntity [Complex:R-HSA-5672724] activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane]

schemaClass EntityFunctionalStatus

Referrals

(entityFunctionalStatus)

[Reaction:R-HSA-6803233] Dissociation of oncogenic RAS:RAF complex

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