Reactome | Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

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Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs Show undefined attributes

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authored

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

category binding

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:6802923] Rothfels, Karen, 2015年10月02日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 6802925

disease

[Disease:1500689] cancer

displayName Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

edited

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

entityFunctionalStatus

[EntityFunctionalStatus:6802867] gain_of_function of RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane]

eventOf

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens

followingEvent

[Reaction:R-HSA-6802926] Mutant RAS:p-RAF complexes phosphorylate MAP2Ks - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs

normalReaction [Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex

output

[Complex:R-HSA-6802667] mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

precedingEvent

[Reaction:R-HSA-6802924] RAF is phosphorylated downstream of oncogenic RAS - Homo sapiens

regulatedBy

[NegativeRegulation:R-HSA-8936734] Negative regulation by 'p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane]'

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-6802925

summation

[Summation:6802231] RAF dimerization and phosphorylation downstream of oncogenic...

Referrals

(hasEvent)

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants

(precedingEvent)

[Reaction:R-HSA-6802926] Mutant RAS:p-RAF complexes phosphorylate MAP2Ks

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Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs Show undefined attributes

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