Reactome Pathway Database

Schema > BlackBoxEvent > Entries

Homo- or heterodimerization of RAF downstream of mutant RAS Show undefined attributes

authored

[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日

category omitted

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:6803237] Rothfels, Karen, 2015年10月05日

crossReference

dbId 6803240

disease

displayName Homo- or heterodimerization of RAF downstream of mutant RAS

edited

[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日

entityFunctionalStatus

[EntityFunctionalStatus:6803239] gain_of_function of RAS mutants:GTP:RAF [plasma membrane]

eventOf

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Homo- or heterodimerization of RAF downstream of mutant RAS

normalReaction [Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers

output

[Complex:R-HSA-6802611] RAS mutants:GTP:RAF homo/heterodimer [plasma membrane]

precedingEvent

[Reaction:R-HSA-6802908] RAS mutants bind inactive RAF - Homo sapiens

regulatedBy

releaseDate 2016年09月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日

schemaClass BlackBoxEvent

species

[Species:48887] Homo sapiens

stId R-HSA-6803240

summation

[Summation:6803250] Similar to the WT pathway, activation of RAF downstream of o...

Referrals

(hasEvent)

[Pathway:R-HSA-9649948] Signaling downstream of RAS mutants

© 2025 Reactome

Cite Us!