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Entries
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
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authored
[InstanceEdit:5658468] Rothfels, Karen, 2014年12月18日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:5672967] Rothfels, Karen, 2015年02月06日
dbId
5672966
displayName
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
edited
[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日
eventOf
[Pathway:R-HSA-5673000] RAF activation - Homo sapiens
followingEvent
[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers - Homo sapiens
[Reaction:R-HSA-5672969] Phosphorylation of RAF - Homo sapiens
input
[DefinedSet:R-HSA-5672731] dephosphorylated "receiver" RAF/KSR1 [cytosol]
[Complex:R-HSA-5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5672425] Active Ras induces heterodimerization of cRaf and BRaf
[LiteratureReference:5672291] Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
[LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization
[LiteratureReference:444336] A dimerization-dependent mechanism drives RAF catalytic activation
[LiteratureReference:5672158] Allosteric activation of functionally asymmetric RAF kinase dimers
[LiteratureReference:5672468] MEK-1 activates C-Raf through a Ras-independent mechanism
[LiteratureReference:5672144] "RAF" neighborhood: protein-protein interaction in the Raf/Mek/Erk pathway
[LiteratureReference:5675383] A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation
[LiteratureReference:5675395] Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein
[LiteratureReference:5675386] MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
orthologousEvent
[Reaction:R-CEL-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Caenorhabditis elegans
[Reaction:R-DME-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Drosophila melanogaster
[Reaction:R-GGA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Gallus gallus
[Reaction:R-SSC-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Sus scrofa
[Reaction:R-BTA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Bos taurus
[Reaction:R-RNO-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Rattus norvegicus
[Reaction:R-MMU-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Mus musculus
output
[Complex:R-HSA-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane]
precedingEvent
[Reaction:R-HSA-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Homo sapiens
[Reaction:R-HSA-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-5674028] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]'
[PositiveRegulation:R-HSA-5675439] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate
2015年06月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-5672966
summation
[Summation:5672621] RAF activation depends on the formation of a side-by-side as...
updateTrackers
[UpdateTracker:9782898] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v58:[modifyText]
[UpdateTracker:9783858] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v55:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9782898] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v58:[modifyText]
[UpdateTracker:9783858] Update Tracker - [Reaction:5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - v55:[modifyText]
(normalReaction)
[Reaction:R-HSA-9656213] RAF1 mutants show enhanced heterodimerization with BRAF
[Reaction:R-HSA-8936731] Inactive BRAF mutants:mutant RAS:GTP bind RAF1
[Reaction:R-HSA-8936676] Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
[BlackBoxEvent:R-HSA-6803240] Homo- or heterodimerization of RAF downstream of mutant RAS
(precedingEvent)
[Reaction:R-HSA-9653108] Raf dimer inhibitors bind RAF heterodimers
[Reaction:R-HSA-5672969] Phosphorylation of RAF
(hasEvent)
[Pathway:R-HSA-5673000] RAF activation
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