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Schema
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Reaction
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Entries
Inactive BRAF mutants:mutant RAS:GTP bind RAF1
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authored
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:8936730] Rothfels, Karen, 2016年08月23日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
8936731
disease
[Disease:1500689] cancer
displayName
Inactive BRAF mutants:mutant RAS:GTP bind RAF1
edited
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
entityFunctionalStatus
[EntityFunctionalStatus:8936728] gain_of_function of chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane]
eventOf
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF - Homo sapiens
followingEvent
[Reaction:R-HSA-6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF - Homo sapiens
input
[Complex:R-HSA-8936725] chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane]
[Complex:R-HSA-6802713] p-S621 RAF1:YWHAB [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
[LiteratureReference:5672195] Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
[LiteratureReference:6790390] RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
[LiteratureReference:6790370] RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
[LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
[LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Inactive BRAF mutants:mutant RAS:GTP bind RAF1
normalReaction
[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
output
[Complex:R-HSA-6802674] mutant RAS:inactive BRAF:RAF1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-6802937] Inactive BRAF mutants bind mutant RAS:GTP - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-8936735] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]'
[PositiveRegulation:R-HSA-8936745] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8936731
summation
[Summation:6802246] The paradoxical activation of ERK signaling downstream of ki...
Referrals
(precedingEvent)
[Reaction:R-HSA-6802941] RAF is paradoxically phosphorylated downstream of kinase-inactive RAF
(hasEvent)
[Pathway:R-HSA-6802955] Paradoxical activation of RAF signaling by kinase inactive BRAF
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