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Entries
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
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authored
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:8936677] Rothfels, Karen, 2016年08月22日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
8936676
disease
[Disease:1500689] cancer
displayName
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
edited
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
entityFunctionalStatus
[EntityFunctionalStatus:8936673] gain_of_function of p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane]
eventOf
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
input
[DefinedSet:R-HSA-8936661] 'receiver' RAF [cytosol]
[Complex:R-HSA-8936669] p21 RAS:GTP:moderate kinase activity BRAF mutants [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
[LiteratureReference:5672236] Mutations of the BRAF gene in human cancer
[LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
normalReaction
[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
output
[Complex:R-HSA-6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
precedingEvent
[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
regulatedBy
[NegativeRegulation:R-HSA-8936737] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]'
[PositiveRegulation:R-HSA-8936746] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8936676
summation
[Summation:6802210] In addition to the prevalent and highly activating V600E mut...
Referrals
(hasEvent)
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
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