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Pathway
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Entries
Signaling by moderate kinase activity BRAF mutants
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authored
[InstanceEdit:6802811] Rothfels, Karen, 2015年08月10日
created
[InstanceEdit:6802945] Rothfels, Karen, 2015年10月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12758002] BioModels Database:BIOMD0000000467
[DatabaseIdentifier:12758008] BioModels Database:BIOMD0000000427
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12758010] BioModels Database:BIOMD0000000832
[DatabaseIdentifier:12757964] BioModels Database:BIOMD0000000659
[DatabaseIdentifier:12757966] BioModels Database:BIOMD0000000149
[DatabaseIdentifier:12758012] BioModels Database:BIOMD0000000557
[DatabaseIdentifier:12757882] BioModels Database:BIOMD0000000664
[DatabaseIdentifier:12757968] BioModels Database:BIOMD0000000651
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758014] BioModels Database:BIOMD0000000466
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12757974] BioModels Database:BIOMD0000000288
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12758016] BioModels Database:BIOMD0000000069
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12758018] BioModels Database:BIOMD0000000468
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
6802946
disease
[Disease:1500689] cancer
displayName
Signaling by moderate kinase activity BRAF mutants
edited
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
eventOf
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
[Reaction:R-HSA-8936676] Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize - Homo sapiens
[Reaction:R-HSA-6802916] RAF is phosphorylated downstream of moderate kinase activity BRAF mutants - Homo sapiens
[Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
[Reaction:R-HSA-6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks - Homo sapiens
[Reaction:R-HSA-6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants - Homo sapiens
[Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2018年03月26日
literatureReference
[LiteratureReference:6799043] COSMIC: exploring the world's knowledge of somatic mutations in human cancer
[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
[LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling
[LiteratureReference:6790435] Tumor adaptation and resistance to RAF inhibitors
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
2
modified
[InstanceEdit:9847082] Weiser, Joel, 2023年10月12日
name
Signaling by moderate kinase activity BRAF mutants
normalPathway
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-6802946
summation
[Summation:6802205] In addition to the highly prevalent and activating V600E BRA...
updateTrackers
[UpdateTracker:9779802] Update Tracker - [Pathway:6802946] Signaling by moderate kinase activity BRAF mutants - v64:[updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-6802957] Oncogenic MAPK signaling
(updatedInstance)
[UpdateTracker:9779802] Update Tracker - [Pathway:6802946] Signaling by moderate kinase activity BRAF mutants - v64:[updateContainedRLE]
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