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Schema
>
Reaction
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Entries
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
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authored
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
catalystActivity
[CatalystActivity:5672970] protein serine/threonine/tyrosine kinase activity of RAF activating kinases [plasma membrane]
category
transition
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:6802917] Rothfels, Karen, 2015年10月02日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
6802916
disease
[Disease:1500689] cancer
displayName
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
edited
[InstanceEdit:5693873] Rothfels, Karen, 2015年05月18日
entityFunctionalStatus
[EntityFunctionalStatus:6802872] gain_of_function of RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
eventOf
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs - Homo sapiens
input
5 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-6802639] RAS:GTP:moderate kinase activity BRAF mutants:RAF:YWHAB [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
[LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling
[LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
[LiteratureReference:6790420] Targeting RAS-ERK signalling in cancer: promises and challenges
[LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
RAF is phosphorylated downstream of moderate kinase activity BRAF mutants
normalReaction
[Reaction:R-HSA-5672969] Phosphorylation of RAF
output
5 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-6802642] RAS:GTP:moderate kinase activity BRAF mutants:p-RAF:YWHAB [plasma membrane]
precedingEvent
[Reaction:R-HSA-6802915] Moderate kinase activity BRAF mutants bind RAS:GTP - Homo sapiens
releaseDate
2016年09月19日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8933498] Stephens, Robert M, 2016年08月05日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6802916
summation
[Summation:6802203] Homo- or heterodimerization (with RAF1, also known as CRAF) ...
Referrals
(hasEvent)
[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
(precedingEvent)
[Reaction:R-HSA-6802914] RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs
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