Reactome Pathway Database

Schema > Reaction > Entries

Phosphorylation of RAF1 mutants Show undefined attributes

authored

[InstanceEdit:9664643] Rothfels, Karen, 2019年10月25日

catalystActivity

[CatalystActivity:5672970] protein serine/threonine/tyrosine kinase activity of RAF activating kinases [plasma membrane]

category transition

compartment

[Compartment:876] plasma membrane

created [InstanceEdit:9656210] Rothfels, Karen, 2019年07月27日

crossReference

dbId 9656212

disease

displayName Phosphorylation of RAF1 mutants

edited

[InstanceEdit:9690121] Rothfels, Karen, 2020年05月26日

entityFunctionalStatus

[EntityFunctionalStatus:9656202] gain_of_function of p21 RAS:GTP:RAF1 mutant heterodimers [plasma membrane]

eventOf

[Pathway:R-HSA-9656223] Signaling by RAF1 mutants - Homo sapiens

followingEvent

[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Phosphorylation of RAF1 mutants

normalReaction [Reaction:R-HSA-5672969] Phosphorylation of RAF

output

precedingEvent

[Reaction:R-HSA-9656213] RAF1 mutants show enhanced heterodimerization with BRAF - Homo sapiens

releaseDate 2020年06月10日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9686656] Gavathiotis, Evripidis, 2020年05月04日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9656212

summation

[Summation:9655954] RAF1 mutants in cancer and germline disorders such as Noonan...

Referrals

(hasEvent)

[Pathway:R-HSA-9656223] Signaling by RAF1 mutants

(precedingEvent)

[Reaction:R-HSA-9656211] MAP2Ks and MAPKs bind to the activated mutant RAF1 complex

© 2025 Reactome

Cite Us!