Reactome Pathway Database

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RAF/MAP kinase cascade Show undefined attributes

created [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

dbId 10947383

displayName RAF/MAP kinase cascade

eventOf

[Pathway:R-CEL-5684996] MAPK1/MAPK3 signaling - Caenorhabditis elegans

evidenceType [EvidenceType:9965817] inferred by electronic annotation

goBiologicalProcess [GO_BiologicalProcess:21714] MAPK cascade

hasDiagram true

hasEHLD false

hasEvent

[Pathway:R-CEL-9648002] RAS processing - Caenorhabditis elegans
[Reaction:R-CEL-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Caenorhabditis elegans
[Reaction:R-CEL-9649735] Intrinsic nucleotide exchange on RAS - Caenorhabditis elegans
[Reaction:R-CEL-5672965] RAS GEFs promote RAS nucleotide exchange - Caenorhabditis elegans
[Reaction:R-CEL-9658253] RAS:GTP binds PI3K - Caenorhabditis elegans
[Reaction:R-CEL-9660557] RAS:GTP binds RAL GDS proteins - Caenorhabditis elegans
[Pathway:R-CEL-5673000] RAF activation - Caenorhabditis elegans
[Pathway:R-CEL-5674135] MAP2K and MAPK activation - Caenorhabditis elegans
[Reaction:R-CEL-5674385] p-T,Y MAPKs dimerize - Caenorhabditis elegans
[BlackBoxEvent:R-CEL-5674387] Phosphorylated MAPKs translocate into the nucleus - Caenorhabditis elegans
[Pathway:R-CEL-5675221] Negative regulation of MAPK pathway - Caenorhabditis elegans

inferredFrom

[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens

isInDisease false

isInferred true

maxDepth 4

name

RAF/MAP kinase cascade

precedingEvent

[Reaction:R-CEL-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Caenorhabditis elegans

releaseDate 2025年09月18日

schemaClass Pathway

species

[Species:68320] Caenorhabditis elegans

stId R-CEL-5673001

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(inferredTo)

[Pathway:R-HSA-5673001] RAF/MAP kinase cascade

(hasEvent)

[Pathway:R-CEL-5684996] MAPK1/MAPK3 signaling

(hasEncapsulatedEvent)

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