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Signaling by ERBB2
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authored
[InstanceEdit:1972351] Orlic-Milacic, M, 2011年11月04日
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
[Compartment:984] extracellular region
created
[InstanceEdit:1227988] Orlic-Milacic, Marija, 2011年03月15日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
dbId
1227986
diseasePathways
[Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2 - Homo sapiens
[Pathway:R-HSA-9665244] Resistance of ERBB2 KD mutants to sapitinib - Homo sapiens
[Pathway:R-HSA-9665245] Resistance of ERBB2 KD mutants to tesevatinib - Homo sapiens
[Pathway:R-HSA-9665246] Resistance of ERBB2 KD mutants to neratinib - Homo sapiens
[Pathway:R-HSA-9665247] Resistance of ERBB2 KD mutants to osimertinib - Homo sapiens
[Pathway:R-HSA-9665249] Resistance of ERBB2 KD mutants to afatinib - Homo sapiens
[Pathway:R-HSA-9665233] Resistance of ERBB2 KD mutants to trastuzumab - Homo sapiens
[Pathway:R-HSA-9665250] Resistance of ERBB2 KD mutants to AEE788 - Homo sapiens
[Pathway:R-HSA-9665251] Resistance of ERBB2 KD mutants to lapatinib - Homo sapiens
[Pathway:R-HSA-9665737] Drug resistance in ERBB2 TMD/JMD mutants - Homo sapiens
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants - Homo sapiens
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants - Homo sapiens
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants - Homo sapiens
displayName
Signaling by ERBB2
edited
[InstanceEdit:1972361] Matthews, L, 2011年11月07日
[InstanceEdit:1972360] D'Eustachio, P, 2011年11月07日
eventOf
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
figure
[Figure:2291886] /figures/Pathway_Illustrations/ERBB2_72_oicr.png
goBiologicalProcess
[GO_BiologicalProcess:2266273] ERBB2 signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-1247497] ERBB3 binds neuregulins - Homo sapiens
[Reaction:R-HSA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Homo sapiens
[Reaction:R-HSA-1963586] SRC family kinases phosphorylate ERBB2 - Homo sapiens
[Reaction:R-HSA-1963581] Trans-autophosphorylation of p-Y877-ERBB2 heterodimers - Homo sapiens
[Reaction:R-HSA-1963582] Trans-autophosphorylation of ERBB2 heterodimers - Homo sapiens
[Pathway:R-HSA-1250196] SHC1 events in ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-1963640] GRB2 events in ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-1963642] PI3K events in ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-1251932] PLCG1 events in ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-1306955] GRB7 events in ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-6785631] ERBB2 Regulates Cell Motility - Homo sapiens
[Pathway:R-HSA-8847993] ERBB2 Activates PTK6 Signaling - Homo sapiens
[Pathway:R-HSA-8863795] Downregulation of ERBB2 signaling - Homo sapiens
[Pathway:R-HSA-9652282] Drug-mediated inhibition of ERBB2 signaling - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2019年12月10日
maxDepth
4
modified
[InstanceEdit:11001822] Weiser, Joel, 2025年08月28日
name
Signaling by ERBB2
orthologousEvent
[Pathway:R-CEL-1227986] Signaling by ERBB2 - Caenorhabditis elegans
[Pathway:R-DRE-1227986] Signaling by ERBB2 - Danio rerio
[Pathway:R-RNO-1227986] Signaling by ERBB2 - Rattus norvegicus
[Pathway:R-BTA-1227986] Signaling by ERBB2 - Bos taurus
[Pathway:R-SSC-1227986] Signaling by ERBB2 - Sus scrofa
[Pathway:R-XTR-1227986] Signaling by ERBB2 - Xenopus tropicalis
[Pathway:R-GGA-1227986] Signaling by ERBB2 - Gallus gallus
[Pathway:R-DME-1227986] Signaling by ERBB2 - Drosophila melanogaster
[Pathway:R-SPO-1227986] Signaling by ERBB2 - Schizosaccharomyces pombe
[Pathway:R-DDI-1227986] Signaling by ERBB2 - Dictyostelium discoideum
[Pathway:R-CFA-1227986] Signaling by ERBB2 - Canis familiaris
[Pathway:R-MMU-1227986] Signaling by ERBB2 - Mus musculus
releaseDate
2011年12月06日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:1972347] Neckers, LM, 2011年11月11日
[InstanceEdit:1972346] Xu, W, 2011年11月11日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-1227986
summation
[Summation:1361844] ERBB2, also known as HER2 or NEU, is a receptor tyrosine kin...
updateTrackers
[UpdateTracker:9780234] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v63:[updateContainedPathway]
[UpdateTracker:9777526] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v70:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782971] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v58:[add_removeHasEvent, updateContainedPathway]
[UpdateTracker:9783739] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v56:[addHasEvent, updateContainedPathway]
[UpdateTracker:9777446] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v71:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783154] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v57:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788329] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v42:[updateContainedPathway]
[UpdateTracker:9784688] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v53:[updateContainedPathway]
Referrals
(hasEvent)
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)
[Pathway:R-HSA-8848021] Signaling by PTK6
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(normalPathway)
[Pathway:R-HSA-9634285] Constitutive Signaling by Overexpressed ERBB2
[Pathway:R-HSA-9665244] Resistance of ERBB2 KD mutants to sapitinib
[Pathway:R-HSA-9665245] Resistance of ERBB2 KD mutants to tesevatinib
[Pathway:R-HSA-9665246] Resistance of ERBB2 KD mutants to neratinib
[Pathway:R-HSA-9665247] Resistance of ERBB2 KD mutants to osimertinib
[Pathway:R-HSA-9665249] Resistance of ERBB2 KD mutants to afatinib
[Pathway:R-HSA-9665233] Resistance of ERBB2 KD mutants to trastuzumab
[Pathway:R-HSA-9665250] Resistance of ERBB2 KD mutants to AEE788
[Pathway:R-HSA-9665251] Resistance of ERBB2 KD mutants to lapatinib
[Pathway:R-HSA-9665737] Drug resistance in ERBB2 TMD/JMD mutants
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants
(updatedInstance)
[UpdateTracker:9780234] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v63:[updateContainedPathway]
[UpdateTracker:9777526] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v70:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9782971] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v58:[add_removeHasEvent, updateContainedPathway]
[UpdateTracker:9783739] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v56:[addHasEvent, updateContainedPathway]
[UpdateTracker:9777446] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v71:[addHasEvent, updateContainedRLE]
[UpdateTracker:9783154] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v57:[updateContainedPathway, updateIndirectRLE]
[UpdateTracker:9788329] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v42:[updateContainedPathway]
[UpdateTracker:9784688] Update Tracker - [Pathway:1227986] Signaling by ERBB2 - v53:[updateContainedPathway]
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