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Schema
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Pathway
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Entries
Constitutive Signaling by Overexpressed ERBB2
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authored
[InstanceEdit:9634284] Orlic-Milacic, Marija, 2019年01月09日
created
[InstanceEdit:9634284] Orlic-Milacic, Marija, 2019年01月09日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
dbId
9634285
disease
[Disease:1500689] cancer
displayName
Constitutive Signaling by Overexpressed ERBB2
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
eventOf
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-1227964] ERBB2 homodimerization - Homo sapiens
[Reaction:R-HSA-1248694] Trans-autophosphorylation of ERBB2 homodimer - Homo sapiens
[Reaction:R-HSA-9634391] SHC1 binds phosphorylated ERBB2 homodimer - Homo sapiens
[Reaction:R-HSA-9634390] ERBB2 homodimer phosphorylates SHC1 - Homo sapiens
[Reaction:R-HSA-9634402] Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer - Homo sapiens
[Reaction:R-HSA-9634418] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1 - Homo sapiens
[Reaction:R-HSA-9652277] ERBB2 binds trastuzumab - Homo sapiens
[Reaction:R-HSA-9652264] ERBB2 binds TKIs - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1227966] Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Constitutive Signaling by Overexpressed ERBB2
normalPathway
[Pathway:R-HSA-1227986] Signaling by ERBB2
releaseDate
2019年12月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9662685] Kancha, Rama Krishna, 2019年09月16日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9634285
summation
[Summation:9634421] Overexpression of ERBB2 (HER2), usually as a consequence of ...
Referrals
(hasEvent)
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
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