Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
ERBB2 Activates PTK6 Signaling
Show undefined attributes
Go to Details
authored
[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016年01月04日
created
[InstanceEdit:8847991] Orlic-Milacic, Marija, 2015年12月03日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758068] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12758070] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
8847993
displayName
ERBB2 Activates PTK6 Signaling
edited
[InstanceEdit:8850988] Orlic-Milacic, Marija, 2016年01月04日
eventOf
[Pathway:R-HSA-8848021] Signaling by PTK6 - Homo sapiens
[Pathway:R-HSA-1227986] Signaling by ERBB2 - Homo sapiens
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-8847995] Activated ERBB2 binds PTK6 (BRK) - Homo sapiens
[Reaction:R-HSA-8848005] ERBB2 promotes PTK6 autophosphorylation - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8847988] Brk is coamplified with ErbB2 to promote proliferation in breast cancer
[LiteratureReference:8848016] Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse
[LiteratureReference:8849521] Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor
[LiteratureReference:8849518] Breast tumor kinase and extracellular signal-regulated kinase 5 mediate Met receptor signaling to cell migration in breast cancer cells
[LiteratureReference:8849553] Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification
[LiteratureReference:8857638] Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
ERBB2 Activates PTK6 Signaling
orthologousEvent
[Pathway:R-MMU-8847993] ERBB2 Activates PTK6 Signaling - Mus musculus
[Pathway:R-CEL-8847993] ERBB2 Activates PTK6 Signaling - Caenorhabditis elegans
[Pathway:R-DRE-8847993] ERBB2 Activates PTK6 Signaling - Danio rerio
[Pathway:R-SSC-8847993] ERBB2 Activates PTK6 Signaling - Sus scrofa
[Pathway:R-BTA-8847993] ERBB2 Activates PTK6 Signaling - Bos taurus
[Pathway:R-RNO-8847993] ERBB2 Activates PTK6 Signaling - Rattus norvegicus
releaseDate
2016年03月23日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8856649] Pires, Isabel M, 2016年02月07日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8847993
summation
[Summation:8849479] PTK6 (BRK) is activated downstream of ERBB2 (HER) (Xiang et ...
Referrals
(hasEvent)
[Pathway:R-HSA-8848021] Signaling by PTK6
[Pathway:R-HSA-1227986] Signaling by ERBB2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル