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Schema
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Pathway
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Entries
Signaling by ERBB2 TMD/JMD mutants
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authored
[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019年10月31日
created
[InstanceEdit:9665685] Orlic-Milacic, Marija, 2019年10月31日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12758066] BioModels Database:BIOMD0000000594
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758068] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12758070] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
9665686
disease
[Disease:1500689] cancer
displayName
Signaling by ERBB2 TMD/JMD mutants
doi
10.3180/R-HSA-9665686.1
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
eventOf
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9665697] ERBB2 TMD/JMD mutants hetrodimerize - Homo sapiens
[Reaction:R-HSA-9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate - Homo sapiens
[Reaction:R-HSA-9665701] Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 - Homo sapiens
[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 - Homo sapiens
[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens
[Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants - Homo sapiens
[Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR - Homo sapiens
[Reaction:R-HSA-9665706] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1 - Homo sapiens
[Reaction:R-HSA-9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-9665702] ERBB2 TMD/JMD mutants bind TKIs - Homo sapiens
[Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab - Homo sapiens
[Reaction:R-HSA-9665703] ERBB2 TMD/JMD mutants bind pertuzumab - Homo sapiens
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9665999] Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
[LiteratureReference:9666001] Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Signaling by ERBB2 TMD/JMD mutants
normalPathway
[Pathway:R-HSA-1227986] Signaling by ERBB2
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9666036] Bose, Ron, 2019年10月25日
[InstanceEdit:9666034] Krishna, Anagha, 2019年10月25日
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019年11月03日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9665686
summation
[Summation:9665687] Recurrent missense mutations in regions encoding the transme...
Referrals
(hasEvent)
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
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