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Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1 Show undefined attributes

authored

[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019年10月31日

category binding

compartment

created [InstanceEdit:9665710] Orlic-Milacic, Marija, 2019年10月31日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9665701

disease

[Disease:1500689] cancer

displayName Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1

edited

[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日

entityFunctionalStatus

[EntityFunctionalStatus:9665883] gain_of_function of p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4) [plasma membrane]

eventOf

[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants - Homo sapiens

followingEvent

[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1 - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1

normalReaction [Reaction:R-HSA-1963578] SHC1 binds phosphorylated ERBB2 heterodimers

output

[Complex:R-HSA-9665887] p-6Y-ERBB2 TMD/JMD mutants (RAS):Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):SHC1 [plasma membrane]

precedingEvent

[Reaction:R-HSA-9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate - Homo sapiens

releaseDate 2020年03月17日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9665701

summation

[Summation:9665736] Activation of downstream RAS signaling was shown for ERBB2 S...

Referrals

(hasEvent)

[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants

(precedingEvent)

[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1

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