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Activating HER2 mutations in HER2 gene amplification negative breast cancer Show undefined attributes

author

[Person:9646450] Bose, R
[Person:9646444] Kavuri, SM
[Person:9646432] Searleman, AC
[Person:9646449] Shen, W
[Person:9646442] Shen, D
[Person:6801984] Koboldt, DC
[Person:9646447] Monsey, J
[Person:9646453] Goel, N
[Person:9646454] Aronson, AB
[Person:3768926] Li, S
[Person:9646436] Ma, CX
[Person:6801884] Ding, L
[Person:6802105] Mardis, ER
[Person:8932063] Ellis, MJ

created [InstanceEdit:9646434] Orlic-Milacic, Marija, 2019年05月23日

dbId 9646435

displayName Activating HER2 mutations in HER2 gene amplification negative breast cancer

journal Cancer Discov

pages 224-37

pubMedIdentifier 23220880

schemaClass LiteratureReference

title Activating HER2 mutations in HER2 gene amplification negative breast cancer

url http://www.ncbi.nlm.nih.gov/pubmed/23220880

volume 3

year 2013

Referrals

(author)

[Person:9646450] Bose, R
[Person:9646449] Shen, W
[Person:9646454] Aronson, AB
[Person:9646453] Goel, N
[Person:6801984] Koboldt, DC
[Person:3768926] Li, S
[Person:9646432] Searleman, AC
[Person:9646436] Ma, CX
[Person:8932063] Ellis, MJ
[Person:9646442] Shen, D
[Person:6801884] Ding, L
[Person:9646447] Monsey, J
[Person:6802105] Mardis, ER
[Person:9646444] Kavuri, SM

(literatureReference)

[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
[Pathway:R-HSA-9665230] Drug resistance in ERBB2 KD mutants
[Pathway:R-HSA-9665233] Resistance of ERBB2 KD mutants to trastuzumab
[FailedReaction:R-HSA-9665232] Resistant ERBB2 KD mutants do not bind trastuzumab
[Pathway:R-HSA-9665251] Resistance of ERBB2 KD mutants to lapatinib
[FailedReaction:R-HSA-9665284] Resistant ERBB2 KD mutants do not bind lapatinib
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs
[Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
[Reaction:R-HSA-9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
[Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
[Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab
[Reaction:R-HSA-9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1
[Reaction:R-HSA-9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1
[Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
[Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR
[EntityWithAccessionedSequence:R-HSA-9665349] ERBB2 G309A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665381] p-6Y-ERBB2 G309A [plasma membrane]
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
[Summation:9664945] For the following EGFR-binding ERBB2 KD mutants that were sh...
[Reaction:R-HSA-9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
[Reaction:R-HSA-9665034] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1
[Summation:9664930] For the following EGFR-binding ERBB2 KD mutants that activat...
[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs
[Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
[Summation:9664919] Many EGFR-binding ERBB2 KD mutants were shown to activate PI...
[EntityWithAccessionedSequence:R-HSA-9654303] p-Y-ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654401] p-Y-ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654194] p-Y-ERBB2 L755S [plasma membrane]
[Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1
[Reaction:R-HSA-9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1
[Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
[EntityWithAccessionedSequence:R-HSA-9665876] p-6Y-ERBB2 R678Q [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665756] ERBB2 R678Q [plasma membrane]
[Reaction:R-HSA-9665697] ERBB2 TMD/JMD mutants hetrodimerize
[Reaction:R-HSA-9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate
[Reaction:R-HSA-9665701] Phosphorylated ERBB2 TMD/JMD heterodimers bind SHC1
[Reaction:R-HSA-9665705] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants phosphorylate SHC1
[Reaction:R-HSA-9665699] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9665698] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1
[Reaction:R-HSA-9665696] ERBB2 TMD/JMD mutants bind trastuzumab
[Reaction:R-HSA-9665702] ERBB2 TMD/JMD mutants bind TKIs
[Reaction:R-HSA-9665700] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants
[Reaction:R-HSA-9665707] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR
[Reaction:R-HSA-9665706] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
[Reaction:R-HSA-9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants
[EntityWithAccessionedSequence:R-HSA-9647199] p-6Y-ERBB2 D769Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647216] p-6Y-ERBB2 L755S [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647198] p-6Y-ERBB2 G778_P780dup [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647200] p-6Y-ERBB2 D769H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647211] p-6Y-ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647209] p-6Y-ERBB2 V842I [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647208] p-6Y-ERBB2 R896C [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9663599] ERBB2 L755_T759del [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647214] p-6Y-ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646667] ERBB2 G778_P780dup [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646714] ERBB2 R896C [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646579] ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646737] ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646423] ERBB2 L755S [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646617] ERBB2 D769H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646703] ERBB2 V842I [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646620] ERBB2 D769Y [plasma membrane]
[Reaction:R-HSA-9664567] ERBB2 KD mutants heterodimerize
[Reaction:R-HSA-9664588] ERBB2 KD mutants trans-autophosphorylate
[Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1

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