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Reaction
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Entries
ERBB2 KD mutants bind TKIs
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authored
[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019年07月31日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9665122] Orlic-Milacic, Marija, 2019年10月30日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9665121
disease
[Disease:1500689] cancer
displayName
ERBB2 KD mutants bind TKIs
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
eventOf
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants - Homo sapiens
input
[Complex:R-HSA-9665141] ERBB2 KD mutants (TKI sensitive):ERBIN:HSP90:CDC37 [plasma membrane]
[DefinedSet:R-ALL-9665127] TKIs (ERBB2) [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
[LiteratureReference:9649445] High-Throughput Functional Evaluation of Variants of Unknown Significance in
ERBB2
[LiteratureReference:9646776] EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
[LiteratureReference:9647026] An Acquired
HER2
T798I
Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
[LiteratureReference:9646962] Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
[LiteratureReference:9646964] Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
[LiteratureReference:9650832] Anti-tumor effect of neratinib against lung cancer cells harboring
HER2
oncogene alterations
[LiteratureReference:9650849] Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations
[LiteratureReference:9665657] The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
ERBB2 KD mutants bind TKIs
output
[Complex:R-HSA-9665144] ERBB2 KD mutants:TKIs:ERBIN:HSP90:CDC37 [plasma membrane]
releaseDate
2019年12月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9662685] Kancha, Rama Krishna, 2019年09月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9665121
summation
[Summation:9665160] Sensitivity to different tyrosine kinase inhibitors varies a...
updateTrackers
[UpdateTracker:9835730] Update Tracker - [Reaction:9665121] ERBB2 KD mutants bind TKIs - v85:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9835730] Update Tracker - [Reaction:9665121] ERBB2 KD mutants bind TKIs - v85:[modifyText]
(hasEvent)
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
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