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Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib Show undefined attributes

author

[Person:9649400] Kancha, RK
[Person:9649394] von Bubnoff, N
[Person:9649399] Bartosch, N
[Person:2685292] Peschel, C
[Person:9649398] Engh, RA
[Person:9649391] Duyster, J

created [InstanceEdit:9649390] Orlic-Milacic, Marija, 2019年06月13日

dbId 9649397

displayName Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

journal PLoS ONE

pages e26760

pubMedIdentifier 22046346

schemaClass LiteratureReference

title Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib

url http://www.ncbi.nlm.nih.gov/pubmed/22046346

volume 6

year 2011

Referrals

(literatureReference)

[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
[Pathway:R-HSA-9665250] Resistance of ERBB2 KD mutants to AEE788
[FailedReaction:R-HSA-9665278] Resistant ERBB2 KD mutants do not bind AEE788
[Pathway:R-HSA-9665251] Resistance of ERBB2 KD mutants to lapatinib
[FailedReaction:R-HSA-9665284] Resistant ERBB2 KD mutants do not bind lapatinib
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
[Summation:9664945] For the following EGFR-binding ERBB2 KD mutants that were sh...
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3
[Summation:9664930] For the following EGFR-binding ERBB2 KD mutants that activat...
[Reaction:R-HSA-9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs
[Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants
[Summation:9664919] Many EGFR-binding ERBB2 KD mutants were shown to activate PI...
[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1
[Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3
[Reaction:R-HSA-9664646] Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K
[EntityWithAccessionedSequence:R-HSA-9654695] p-Y-ERBB2 T862A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654833] p-Y-ERBB2 H878Y [plasma membrane]
[Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1
[Reaction:R-HSA-9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1
[Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR
[Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1
[Reaction:R-HSA-9664588] ERBB2 KD mutants trans-autophosphorylate
[Reaction:R-HSA-9664567] ERBB2 KD mutants heterodimerize
[EntityWithAccessionedSequence:R-HSA-9646824] ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9649434] ERBB2 T862A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647215] p-6Y-ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654692] p-6Y-ERBB2 T862A [plasma membrane]

(author)

[Person:9649391] Duyster, J
[Person:9649400] Kancha, RK
[Person:9649398] Engh, RA
[Person:2685292] Peschel, C
[Person:9649399] Bartosch, N
[Person:9649394] von Bubnoff, N

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