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Entries
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
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authored
[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019年07月31日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9664934] Orlic-Milacic, Marija, 2019年10月28日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9664933
disease
[Disease:1500689] cancer
displayName
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
entityFunctionalStatus
[EntityFunctionalStatus:9664931] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
eventOf
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens
input
[Complex:R-HSA-9664921] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]
[Complex:R-HSA-1806218] PIK3CA:PIK3R1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
[LiteratureReference:9646787] Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
[LiteratureReference:9646445] Combined Blockade of Activating
ERBB2
Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
[LiteratureReference:9646758] Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
[LiteratureReference:9650849] Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations
[LiteratureReference:9652195] Human breast cancer cells harboring a gatekeeper T798M mutation in HER2 overexpress EGFR ligands and are sensitive to dual inhibition of EGFR and HER2
[LiteratureReference:9647026] An Acquired
HER2
T798I
Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
[LiteratureReference:9646962] Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
[LiteratureReference:9646964] Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
[LiteratureReference:9665642] HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
normalReaction
[Reaction:R-HSA-1306965] Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
output
[Complex:R-HSA-9664932] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane]
precedingEvent
[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 - Homo sapiens
releaseDate
2019年12月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9662685] Kancha, Rama Krishna, 2019年09月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9664933
summation
[Summation:9664930] For the following EGFR-binding ERBB2 KD mutants that activat...
updateTrackers
[UpdateTracker:9835781] Update Tracker - [Reaction:9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - v85:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9835781] Update Tracker - [Reaction:9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - v85:[modifyText]
(precedingEvent)
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3
(hasEvent)
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
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