Reactome Pathway Database

Schema > Complex > Entries

p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] Show undefined attributes

compartment

[Compartment:876] plasma membrane

componentOf

[Complex:R-HSA-9664932] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane] - Homo sapiens

consumedByEvent

[Reaction:R-HSA-9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - Homo sapiens

created [InstanceEdit:9664916] Orlic-Milacic, Marija, 2019年10月28日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9664921

disease

[Disease:1500689] cancer

displayName p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]

hasComponent

inDisease true

includedLocation

isChimeric false

maxDepth 4

name

p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1

producedByEvent

[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 - Homo sapiens

schemaClass Complex

species

[Species:48887] Homo sapiens

stId R-HSA-9664921

updateTrackers

[UpdateTracker:9905391] Update Tracker - [Complex:9664921] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] - v85:[updateContainedComponent]

Referrals

(updatedInstance)

[UpdateTracker:9905391] Update Tracker - [Complex:9664921] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] - v85:[updateContainedComponent]

(hasComponent)

[Complex:R-HSA-9664932] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1:PI3K [plasma membrane]

(input)

[Reaction:R-HSA-9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K

(diseaseEntity)

[EntityFunctionalStatus:9664931] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:GAB1 [plasma membrane]

(output)

[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1

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