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Entries
Signaling by ERBB2 KD Mutants
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authored
[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019年07月31日
created
[InstanceEdit:9664566] Orlic-Milacic, Marija, 2019年10月25日
crossReference
[DatabaseIdentifier:12757950] BioModels Database:BIOMD0000000255
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:12757960] BioModels Database:BIOMD0000000653
[DatabaseIdentifier:12757962] BioModels Database:BIOMD0000000656
[DatabaseIdentifier:12758066] BioModels Database:BIOMD0000000594
[DatabaseIdentifier:12757970] BioModels Database:BIOMD0000000648
[DatabaseIdentifier:12758068] BioModels Database:BIOMD0000000223
[DatabaseIdentifier:12757956] BioModels Database:BIOMD0000000175
[DatabaseIdentifier:12757972] BioModels Database:BIOMD0000000655
[DatabaseIdentifier:12758070] BioModels Database:BIOMD0000000595
[DatabaseIdentifier:12757976] BioModels Database:BIOMD0000000652
[DatabaseIdentifier:12757884] BioModels Database:BIOMD0000000883
[DatabaseIdentifier:12757978] BioModels Database:BIOMD0000000399
[DatabaseIdentifier:12757980] BioModels Database:BIOMD0000000019
[DatabaseIdentifier:12757928] BioModels Database:BIOMD0000000477
[DatabaseIdentifier:12757982] BioModels Database:BIOMD0000000424
[DatabaseIdentifier:12757984] BioModels Database:BIOMD0000000654
dbId
9664565
disease
[Disease:1500689] cancer
displayName
Signaling by ERBB2 KD Mutants
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
eventOf
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-9664567] ERBB2 KD mutants heterodimerize - Homo sapiens
[Reaction:R-HSA-9664588] ERBB2 KD mutants trans-autophosphorylate - Homo sapiens
[Reaction:R-HSA-9664646] Phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 bind PI3K - Homo sapiens
[Reaction:R-HSA-9664664] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and ERBB3 converts PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-9664918] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:GAB1 - Homo sapiens
[Reaction:R-HSA-9664933] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K - Homo sapiens
[Reaction:R-HSA-9664940] PI3K bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR converts PIP2 to PIP3 - Homo sapiens
[Reaction:R-HSA-9664950] Phosphorylated heterodimers of ERBB2 KD mutants bind SHC1 - Homo sapiens
[Reaction:R-HSA-9664976] Phosphorylated heterodimers of ERBB2 KD mutants phosphorylate SHC1 - Homo sapiens
[Reaction:R-HSA-9664983] Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1 - Homo sapiens
[Reaction:R-HSA-9664991] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants - Homo sapiens
[Reaction:R-HSA-9665000] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1 - Homo sapiens
[Reaction:R-HSA-9665009] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 KD mutants and EGFR - Homo sapiens
[Reaction:R-HSA-9665034] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 - Homo sapiens
[Reaction:R-HSA-9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 - Homo sapiens
[Reaction:R-HSA-9665121] ERBB2 KD mutants bind TKIs - Homo sapiens
[Reaction:R-HSA-9649393] ERBB2 KD mutants bind trastuzumab - Homo sapiens
isInDisease
true
isInferred
false
lastUpdatedDate
2023年06月07日
literatureReference
[LiteratureReference:9646445] Combined Blockade of Activating
ERBB2
Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9646515] Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma
[LiteratureReference:9646518] COSMIC: somatic cancer genetics at high-resolution
[LiteratureReference:9646647] Carboxyl group footprinting mass spectrometry and molecular dynamics identify key interactions in the HER2-HER3 receptor tyrosine kinase interface
[LiteratureReference:9646654] Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer
[LiteratureReference:9646758] Intra-tumor genetic heterogeneity and alternative driver genetic alterations in breast cancers with heterogeneous HER2 gene amplification
[LiteratureReference:9646776] EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation
[LiteratureReference:9646940] Patient-specific molecular alterations are associated with metastatic clear cell renal cell cancer progressing under tyrosine kinase inhibitor therapy
[LiteratureReference:9647018] Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies
[LiteratureReference:9647024] Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
[LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
[LiteratureReference:9646947] Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma
[LiteratureReference:9646957] Integrated genomic analyses of ovarian carcinoma
[LiteratureReference:9647026] An Acquired
HER2
T798I
Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer
[LiteratureReference:9646787] Neratinib is effective in breast tumors bearing both amplification and mutation of ERBB2 (HER2)
[LiteratureReference:9646964] Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
[LiteratureReference:9646962] Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
[LiteratureReference:9649397] Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib
maxDepth
2
modified
[InstanceEdit:12757879] Weiser, Joel, 2025年08月05日
name
Signaling by ERBB2 KD Mutants
normalPathway
[Pathway:R-HSA-1227986] Signaling by ERBB2
releaseDate
2019年12月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9662685] Kancha, Rama Krishna, 2019年09月16日
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-9664565
summation
[Summation:9646452] Mutations in the kinase domain (KD) of ERBB2 result in const...
updateTrackers
[UpdateTracker:9835787] Update Tracker - [Pathway:9664565] Signaling by ERBB2 KD Mutants - v85:[modifyText, updateContainedRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
(updatedInstance)
[UpdateTracker:9835787] Update Tracker - [Pathway:9664565] Signaling by ERBB2 KD Mutants - v85:[modifyText, updateContainedRLE]
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