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Schema
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Reaction
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Entries
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
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authored
[InstanceEdit:9656339] Orlic-Milacic, Marija, 2019年07月31日
catalystActivity
[CatalystActivity:9665039] protein tyrosine kinase activity of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9665040] Orlic-Milacic, Marija, 2019年10月28日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9665032
disease
[Disease:1500689] cancer
displayName
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
entityFunctionalStatus
[EntityFunctionalStatus:9665042] gain_of_function of p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
eventOf
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants - Homo sapiens
input
4 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-9665033] p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9646962] Phosphorylation of mutationally introduced tyrosine in the activation loop of HER2 confers gain-of-function activity
[LiteratureReference:9646964] Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1
normalReaction
[Reaction:R-HSA-1251922] PLCG1 phosphorylation by p-EGFR:p-ERBB2
output
4 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[EntityWithAccessionedSequence:R-HSA-167679] p-4Y-PLCG1 [plasma membrane]
[Complex:R-HSA-9665037] p-6Y-ERBB2 KD mutants (PLCG1):EGF:p-6Y-EGFR [plasma membrane]
precedingEvent
[Reaction:R-HSA-9665034] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind PLCG1 - Homo sapiens
releaseDate
2019年12月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9662685] Kancha, Rama Krishna, 2019年09月16日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9665032
summation
[Summation:9665041] It is assumed that the following EGFR-binding ERBB2 mutants ...
updateTrackers
[UpdateTracker:9835737] Update Tracker - [Reaction:9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 - v85:[modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9835737] Update Tracker - [Reaction:9665032] Phosphorylated heterodimers of ERBB2 KD mutants and EGFR phosphorylate PLCG1 - v85:[modifyText]
(hasEvent)
[Pathway:R-HSA-9664565] Signaling by ERBB2 KD Mutants
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