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Entries
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
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authored
[InstanceEdit:9665478] Orlic-Milacic, Marija, 2019年10月31日
category
binding
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9665710] Orlic-Milacic, Marija, 2019年10月31日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9665706
disease
[Disease:1500689] cancer
displayName
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
entityFunctionalStatus
[EntityFunctionalStatus:9665923] gain_of_function of p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane]
eventOf
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1 - Homo sapiens
input
[Complex:R-HSA-9665925] p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-202320] PLCG1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind PLCG1
normalReaction
[Reaction:R-HSA-1251944] PLCG1 binds to p-ERBB2:p-EGFR
output
[Complex:R-HSA-9665924] p-6Y-ERBB2 R678Q:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9665709] ERBB2 TMD/JMD heterodimers trans-autophosphorylate - Homo sapiens
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9666036] Bose, Ron, 2019年10月25日
[InstanceEdit:9666034] Krishna, Anagha, 2019年10月25日
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019年11月03日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9665706
summation
[Summation:9665744] Activation of downstream PLCG1 signaling was demonstrated fo...
Referrals
(precedingEvent)
[Reaction:R-HSA-9665704] Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR phosphorylate PLCG1
(hasEvent)
[Pathway:R-HSA-9665686] Signaling by ERBB2 TMD/JMD mutants
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