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Entries
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
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authored
[InstanceEdit:9665241] Orlic-Milacic, Marija, 2019年10月30日
category
binding
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:9665414] Orlic-Milacic, Marija, 2019年10月30日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
9665410
disease
[Disease:1500689] cancer
displayName
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
edited
[InstanceEdit:9665760] Orlic-Milacic, Marija, 2019年11月01日
entityFunctionalStatus
[EntityFunctionalStatus:9665448] gain_of_function of p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
eventOf
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants - Homo sapiens
followingEvent
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1 - Homo sapiens
input
[Complex:R-HSA-9665380] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-202320] PLCG1 [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:9646435] Activating HER2 mutations in HER2 gene amplification negative breast cancer
[LiteratureReference:9665365] Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
normalReaction
[Reaction:R-HSA-1251944] PLCG1 binds to p-ERBB2:p-EGFR
output
[Complex:R-HSA-9665460] p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:PLCG1 [plasma membrane]
precedingEvent
[Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate - Homo sapiens
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9666036] Bose, Ron, 2019年10月25日
[InstanceEdit:9666034] Krishna, Anagha, 2019年10月25日
[InstanceEdit:9666741] Kancha, Rama Krishna, 2019年11月03日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9665410
summation
[Summation:9665492] PLCgamma1 signaling is activated dowsntream of ERBB2 ECD mut...
Referrals
(hasEvent)
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
(precedingEvent)
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
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