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Schema
>
LiteratureReference
>
Entries
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
Show undefined attributes
author
[Person:1169426] Greulich, H
[Person:9652912] Kaplan, B
[Person:6789441] Mertins, P
[Person:9665368] Chen, TH
[Person:9665369] Tanaka, KE
[Person:5362601] Yun, CH
[Person:3214853] Zhang, X
[Person:8853022] Lee, SH
[Person:1982011] Cho, J
[Person:8850981] Ambrogio, L
[Person:9665373] Liao, R
[Person:9665372] Imielinski, M
[Person:9665364] Banerji, S
[Person:9665371] Berger, AH
[Person:3656319] Lawrence, MS
[Person:6802137] Zhang, J
[Person:9665366] Pho, NH
[Person:9665363] Walker, SR
[Person:1614729] Winckler, W
[Person:2008151] Getz, G
[Person:9665370] Frank, D
[Person:2011584] Hahn, WC
[Person:2408401] Eck, MJ
[Person:9665374] Mani, DR
[Person:5432417] Jaffe, JD
[Person:200243] Carr, SA
[Person:1182963] Wong, KK
[Person:1169419] Meyerson, M
created
[InstanceEdit:9665367] Orlic-Milacic, Marija, 2019年10月30日
dbId
9665365
displayName
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
journal
Proc. Natl. Acad. Sci. U.S.A.
pages
14476-81
pubMedIdentifier
22908275
schemaClass
LiteratureReference
title
Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2
url
http://www.ncbi.nlm.nih.gov/pubmed/22908275
volume
109
year
2012
Referrals
(author)
[Person:9665363] Walker, SR
[Person:1169426] Greulich, H
[Person:9665366] Pho, NH
[Person:9665364] Banerji, S
[Person:9665371] Berger, AH
[Person:3656319] Lawrence, MS
[Person:2008151] Getz, G
[Person:9665370] Frank, D
[Person:9665369] Tanaka, KE
[Person:9665368] Chen, TH
[Person:9665374] Mani, DR
[Person:9665373] Liao, R
[Person:9665372] Imielinski, M
[Person:1614729] Winckler, W
[Person:8853022] Lee, SH
[Person:1169419] Meyerson, M
[Person:2011584] Hahn, WC
[Person:1182963] Wong, KK
[Person:8850981] Ambrogio, L
[Person:9652912] Kaplan, B
[Person:1982011] Cho, J
[Person:6789441] Mertins, P
[Person:200243] Carr, SA
[Person:5432417] Jaffe, JD
[Person:3214853] Zhang, X
[Person:2408401] Eck, MJ
[Person:5362601] Yun, CH
[Person:6802137] Zhang, J
(literatureReference)
[Pathway:R-HSA-1227990] Signaling by ERBB2 in Cancer
[Pathway:R-HSA-9665348] Signaling by ERBB2 ECD mutants
[EntityWithAccessionedSequence:R-HSA-9665385] p-6Y-ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665379] p-6Y-ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665382] p-6Y-ERBB2 G309E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665344] ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665350] ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665342] ERBB2 G309E [plasma membrane]
[Reaction:R-HSA-9665388] ERBB2 ECD mutants heterodimerize with EGFR
[Reaction:R-HSA-9665389] Heterodimers of ERBB2 ECD mutants and EGFR trans-autophosphorylate
[Reaction:R-HSA-9665417] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind GRB2:GAB1
[Reaction:R-HSA-9665415] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR, in complex with GRB2:GAB1, bind PI3K
[Reaction:R-HSA-9665407] PI3K bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR converts PIP2 to PIP3
[Reaction:R-HSA-9665416] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind SHC1
[Reaction:R-HSA-9665406] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate SHC1
[Reaction:R-HSA-9665405] ERBB2 ECD mutants bind trastuzumab
[Reaction:R-HSA-9665413] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1
[Reaction:R-HSA-9665404] RAS guanyl nucleotide exchange mediated by the p-6Y- ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-SHC1:GRB2:SOS1
[Reaction:R-HSA-9665410] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1
[Reaction:R-HSA-9665411] Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR phosphorylate PLCG1
[Reaction:R-HSA-9665409] GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR
[Reaction:R-HSA-9665408] RAS activation by SOS1 bound to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR through GRB2
[Reaction:R-HSA-9665412] ERBB2 ECD mutants bind TKIs
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