Reactome Pathway Database

Schema > Pathway > Entries

MAP2K and MAPK activation Show undefined attributes

authored

[InstanceEdit:5674037] Rothfels, Karen, 2015年02月10日

created [InstanceEdit:5674137] Rothfels, Karen, 2015年02月10日

crossReference

dbId 5674135

deleted

displayName MAP2K and MAPK activation

edited

[InstanceEdit:5674528] Rothfels, Karen, 2015年02月12日

eventOf

[Pathway:R-HSA-5673001] RAF/MAP kinase cascade - Homo sapiens

hasDiagram false

hasEHLD false

hasEvent

[Reaction:R-HSA-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Homo sapiens
[Reaction:R-HSA-9657599] Dual mechanism MAP2K inhibitors bind MAP2Ks - Homo sapiens
[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer - Homo sapiens
[Reaction:R-HSA-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Homo sapiens
[Reaction:R-HSA-9657603] Dual mechanism MAPK inhibitors bind MAPKs - Homo sapiens
[Reaction:R-HSA-5672973] MAP2Ks phosphorylate MAPKs - Homo sapiens
[Reaction:R-HSA-5672980] Dissociation of RAS:RAF complex - Homo sapiens
[Reaction:R-HSA-9657608] Single mechanism MAPK inhibitors bind phosphorylated MAPK - Homo sapiens
[Reaction:R-HSA-5674132] WDR83:LAMTOR2:LAMTOR3 binds MAPK components - Homo sapiens
[BlackBoxEvent:R-HSA-5674130] MAP2Ks and MAPKs are phosphorylated at the endosome membrane - Homo sapiens
[Reaction:R-HSA-5674366] IL17RD binds p-2S MAP2Ks and MAPKs - Homo sapiens
[Reaction:R-HSA-5674373] MAP2Ks phosphorylate MAPK at the Golgi membrane - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2020年06月17日

literatureReference

maxDepth 2

modified [InstanceEdit:12757879] Weiser, Joel, 2025年08月05日

name

MAP2K and MAPK activation

orthologousEvent

releaseDate 2015年06月17日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:5690572] Roskoski, Robert Jr, 2015年04月28日

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-5674135

summation

[Summation:5675202] Activated RAF proteins are restricted substrate kinases whos...

updateTrackers

Referrals

(hasEvent)

[Pathway:R-HSA-5673001] RAF/MAP kinase cascade

(replacementInstances)

(updatedInstance)

© 2025 Reactome

Cite Us!