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RET signaling Show undefined attributes

authored

[InstanceEdit:8853613] Jupe, Steve, 2016年01月25日

created [InstanceEdit:8853613] Jupe, Steve, 2016年01月25日

dbId 8853659

displayName RET signaling

doi 10.3180/R-HSA-8853659.2

edited

[InstanceEdit:8869649] Jupe, Steve, 2016年04月28日

eventOf

[Pathway:R-HSA-422475] Axon guidance - Homo sapiens

hasDiagram true

hasEHLD false

hasEvent

[Reaction:R-HSA-8853745] RET binds GFRA1,GFRA3 - Homo sapiens
[Reaction:R-HSA-8871226] RET binds GFRA1,GFRA2 - Homo sapiens
[Reaction:R-HSA-8871227] RET binds GFRA4 - Homo sapiens
[Reaction:R-HSA-8853789] GDNF,NRTN bind RET:GFRA1,GFRA2 - Homo sapiens
[Reaction:R-HSA-8853800] ARTN binds RET:GFRA1,GFRA3 - Homo sapiens
[Reaction:R-HSA-8853801] PSPN binds RET:GFRA4 - Homo sapiens
[Reaction:R-HSA-8853762] RET dimerizes - Homo sapiens
[Reaction:R-HSA-8853792] RET tyrosine phosphorylation - Homo sapiens
[Reaction:R-HSA-8854908] PKA phosphorylates RET:GDNF:GFRA dimer - Homo sapiens
[Reaction:R-HSA-8855617] 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 - Homo sapiens
[Reaction:R-HSA-8855915] 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors - Homo sapiens
[Reaction:R-HSA-8855564] 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 - Homo sapiens
[Reaction:R-HSA-8853737] 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 - Homo sapiens
[BlackBoxEvent:R-HSA-8854981] SHC1 in the RET complex is phosphorylated - Homo sapiens
[Reaction:R-HSA-8853734] 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 - Homo sapiens
[Reaction:R-HSA-8854899] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 - Homo sapiens
[BlackBoxEvent:R-HSA-8853793] p-5Y-RET complexes bind GRB2 - Homo sapiens
[BlackBoxEvent:R-HSA-8854897] p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 - Homo sapiens
[BlackBoxEvent:R-HSA-8853774] GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated - Homo sapiens
[BlackBoxEvent:R-HSA-8854905] p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K - Homo sapiens
[Reaction:R-HSA-8855508] p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 - Homo sapiens
[Reaction:R-HSA-8853753] 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 - Homo sapiens
[Reaction:R-HSA-8853755] 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 - Homo sapiens
[Reaction:R-HSA-8855747] 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP - Homo sapiens

isInDisease false

isInferred false

lastUpdatedDate 2017年09月27日

literatureReference

maxDepth 2

modified [InstanceEdit:10867632] Weiser, Joel, 2025年08月27日

name

RET signaling

orthologousEvent

releaseDate 2016年06月15日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Pathway

species

[Species:48887] Homo sapiens

stId R-HSA-8853659

summation

[Summation:8853581] The RET proto-oncogene encodes a receptor tyrosine kinase ex...

updateTrackers

Referrals

(updatedInstance)

(hasEvent)

[Pathway:R-HSA-422475] Axon guidance

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