Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Pathway
>
Entries
Signaling by PDGF
Show undefined attributes
Go to Details
authored
[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008年11月24日 10:14:27
created
[InstanceEdit:186802] Jassal, B, 2006年08月15日 13:51:10
crossReference
[DatabaseIdentifier:12757974] BioModels Database:BIOMD0000000288
dbId
186797
diseasePathways
[Pathway:R-HSA-9671555] Signaling by PDGFR in disease - Homo sapiens
[Pathway:R-HSA-9674428] PDGFR mutants bind TKIs - Homo sapiens
[Pathway:R-HSA-9674415] Drug resistance of PDGFR mutants - Homo sapiens
[Pathway:R-HSA-9674396] Imatinib-resistant PDGFR mutants - Homo sapiens
[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants - Homo sapiens
[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins - Homo sapiens
[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants - Homo sapiens
[Pathway:R-HSA-9673768] Signaling by membrane-tethered fusions of PDGFRA or PDGFRB - Homo sapiens
[Pathway:R-HSA-9674403] Regorafenib-resistant PDGFR mutants - Homo sapiens
[Pathway:R-HSA-9674401] Sunitinib-resistant PDGFR mutants - Homo sapiens
[Pathway:R-HSA-9674404] Sorafenib-resistant PDGFR mutants - Homo sapiens
displayName
Signaling by PDGF
doi
10.3180/REACT_16888.1
edited
[InstanceEdit:382627] Garapati, P V, Jassal, B, 2008年11月24日 10:14:27
eventOf
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases - Homo sapiens
figure
[Figure:2291917] /figures/Pathway_Illustrations/PDGF_72_oicr.png
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-382053] Translocation of PDGF from ER to Golgi - Homo sapiens
[Reaction:R-HSA-186785] PDGF-AA clevage by Furin - Homo sapiens
[Reaction:R-HSA-8865275] PDGF-BB clevage by Furin - Homo sapiens
[Reaction:R-HSA-8865276] PDGF-AB clevage by Furin - Homo sapiens
[BlackBoxEvent:R-HSA-382057] Release of novel PDGFs as latent factors - Homo sapiens
[Reaction:R-HSA-382061] Extracellular processing of novel PDGFs - Homo sapiens
[Reaction:R-HSA-382054] PDGF binds to extracellular matrix proteins - Homo sapiens
[BlackBoxEvent:R-HSA-186773] PDGF dimer binds two receptors simultaneously - Homo sapiens
[Reaction:R-HSA-186786] Autophosphorylation of PDGF beta receptors - Homo sapiens
[Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors - Homo sapiens
[Reaction:R-HSA-389086] Autophosphorylation of PDGF alpha/beta receptors - Homo sapiens
[Pathway:R-HSA-186763] Downstream signal transduction - Homo sapiens
[Reaction:R-HSA-8864036] PTPN12 dephosphorylates PDGFRB at Y1021 - Homo sapiens
[Reaction:R-HSA-9674015] Olaratumab binds PDGFRA - Homo sapiens
[Reaction:R-HSA-9674093] PDGFRs bind type I TKI - Homo sapiens
[Reaction:R-HSA-9674095] PDGFRs bind type II TKI - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2022年04月07日
literatureReference
[LiteratureReference:380730] Mechanism of action and in vivo role of platelet-derived growth factor
[LiteratureReference:380735] Signal transduction via platelet-derived growth factor receptors
[LiteratureReference:380726] The PDGF family: four gene products form five dimeric isoforms
maxDepth
3
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
Signaling by PDGF
orthologousEvent
[Pathway:R-MMU-186797] Signaling by PDGF - Mus musculus
[Pathway:R-RNO-186797] Signaling by PDGF - Rattus norvegicus
[Pathway:R-CFA-186797] Signaling by PDGF - Canis familiaris
[Pathway:R-BTA-186797] Signaling by PDGF - Bos taurus
[Pathway:R-SSC-186797] Signaling by PDGF - Sus scrofa
[Pathway:R-DRE-186797] Signaling by PDGF - Danio rerio
[Pathway:R-XTR-186797] Signaling by PDGF - Xenopus tropicalis
[Pathway:R-GGA-186797] Signaling by PDGF - Gallus gallus
[Pathway:R-CEL-186797] Signaling by PDGF - Caenorhabditis elegans
[Pathway:R-DME-186797] Signaling by PDGF - Drosophila melanogaster
releaseDate
2009年04月01日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:382617] Heldin, CH, 2008年11月23日 19:29:34
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-186797
summation
[Summation:186835] Platelet-derived Growth Factor (PDGF) is a potent stimulator...
updateTrackers
[UpdateTracker:9779115] Update Tracker - [Pathway:186797] Signaling by PDGF - v66:[updateIndirectRLE]
[UpdateTracker:9775080] Update Tracker - [Pathway:186797] Signaling by PDGF - v80:[updateIndirectRLE]
[UpdateTracker:9780621] Update Tracker - [Pathway:186797] Signaling by PDGF - v62:[updateContainedPathway]
[UpdateTracker:9788500] Update Tracker - [Pathway:186797] Signaling by PDGF - v42:[updateContainedPathway]
[UpdateTracker:9781296] Update Tracker - [Pathway:186797] Signaling by PDGF - v61:[updateContainedPathway]
[UpdateTracker:9784740] Update Tracker - [Pathway:186797] Signaling by PDGF - v53:[updateContainedPathway]
[UpdateTracker:9783080] Update Tracker - [Pathway:186797] Signaling by PDGF - v57:[addHasEvent, updateContainedRLE]
[UpdateTracker:9787440] Update Tracker - [Pathway:186797] Signaling by PDGF - v45:[updateIndirectRLE]
[UpdateTracker:9782702] Update Tracker - [Pathway:186797] Signaling by PDGF - v58:[addHasEvent, updateContainedPathway]
[UpdateTracker:9791112] Update Tracker - [Pathway:186797] Signaling by PDGF - v32:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779857] Update Tracker - [Pathway:186797] Signaling by PDGF - v64:[updateIndirectRLE]
[UpdateTracker:9789096] Update Tracker - [Pathway:186797] Signaling by PDGF - v38:[updateContainedPathway]
[UpdateTracker:9777391] Update Tracker - [Pathway:186797] Signaling by PDGF - v72:[addHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783424] Update Tracker - [Pathway:186797] Signaling by PDGF - v56:[updateContainedPathway]
[UpdateTracker:9787947] Update Tracker - [Pathway:186797] Signaling by PDGF - v44:[updateIndirectRLE]
Referrals
(hasEvent)
[Pathway:R-HSA-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)
[Pathway:R-HSA-5673001] RAF/MAP kinase cascade
[Pathway:R-HSA-1257604] PIP3 activates AKT signaling
(normalPathway)
[Pathway:R-HSA-9671555] Signaling by PDGFR in disease
[Pathway:R-HSA-9674428] PDGFR mutants bind TKIs
[Pathway:R-HSA-9674415] Drug resistance of PDGFR mutants
[Pathway:R-HSA-9674396] Imatinib-resistant PDGFR mutants
[Pathway:R-HSA-9673767] Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
[Pathway:R-HSA-9673766] Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants
[Pathway:R-HSA-9673768] Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
[Pathway:R-HSA-9674403] Regorafenib-resistant PDGFR mutants
[Pathway:R-HSA-9674401] Sunitinib-resistant PDGFR mutants
[Pathway:R-HSA-9674404] Sorafenib-resistant PDGFR mutants
(updatedInstance)
[UpdateTracker:9779115] Update Tracker - [Pathway:186797] Signaling by PDGF - v66:[updateIndirectRLE]
[UpdateTracker:9775080] Update Tracker - [Pathway:186797] Signaling by PDGF - v80:[updateIndirectRLE]
[UpdateTracker:9780621] Update Tracker - [Pathway:186797] Signaling by PDGF - v62:[updateContainedPathway]
[UpdateTracker:9788500] Update Tracker - [Pathway:186797] Signaling by PDGF - v42:[updateContainedPathway]
[UpdateTracker:9781296] Update Tracker - [Pathway:186797] Signaling by PDGF - v61:[updateContainedPathway]
[UpdateTracker:9784740] Update Tracker - [Pathway:186797] Signaling by PDGF - v53:[updateContainedPathway]
[UpdateTracker:9783080] Update Tracker - [Pathway:186797] Signaling by PDGF - v57:[addHasEvent, updateContainedRLE]
[UpdateTracker:9787440] Update Tracker - [Pathway:186797] Signaling by PDGF - v45:[updateIndirectRLE]
[UpdateTracker:9782702] Update Tracker - [Pathway:186797] Signaling by PDGF - v58:[addHasEvent, updateContainedPathway]
[UpdateTracker:9791112] Update Tracker - [Pathway:186797] Signaling by PDGF - v32:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9779857] Update Tracker - [Pathway:186797] Signaling by PDGF - v64:[updateIndirectRLE]
[UpdateTracker:9789096] Update Tracker - [Pathway:186797] Signaling by PDGF - v38:[updateContainedPathway]
[UpdateTracker:9777391] Update Tracker - [Pathway:186797] Signaling by PDGF - v72:[addHasEvent, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9783424] Update Tracker - [Pathway:186797] Signaling by PDGF - v56:[updateContainedPathway]
[UpdateTracker:9787947] Update Tracker - [Pathway:186797] Signaling by PDGF - v44:[updateIndirectRLE]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル