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Schema
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Reaction
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Entries
PDGFRs bind type I TKI
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authored
[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日
category
binding
compartment
[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created
[InstanceEdit:9674092] Rothfels, Karen, 2020年01月10日
dbId
9674093
displayName
PDGFRs bind type I TKI
edited
[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日
eventOf
[Pathway:R-HSA-186797] Signaling by PDGF - Homo sapiens
input
[Complex:R-HSA-389079] PDGF alpha receptor: PDGF dimers [plasma membrane]
[DefinedSet:R-ALL-9674075] type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9674057] Pazopanib inhibits the activation of PDGFR?-expressing astrocytes in the brain metastatic microenvironment of breast cancer cells
[LiteratureReference:9674032] Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
[LiteratureReference:9674068] The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
[LiteratureReference:9674023] Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo
[LiteratureReference:9671319] A precision therapy against cancers driven by
KIT/PDGFRA
mutations
[LiteratureReference:9671447] Structural and clinical consequences of activation loop mutations in class III receptor tyrosine kinases
[LiteratureReference:9673583] The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders
maxDepth
1
modified
[InstanceEdit:10867632] Weiser, Joel, 2025年08月27日
name
PDGFRs bind type I TKI
orthologousEvent
[Reaction:R-DME-9674093] PDGFRs bind type I TKI - Drosophila melanogaster
[Reaction:R-CEL-9674093] PDGFRs bind type I TKI - Caenorhabditis elegans
[Reaction:R-GGA-9674093] PDGFRs bind type I TKI - Gallus gallus
[Reaction:R-DRE-9674093] PDGFRs bind type I TKI - Danio rerio
[Reaction:R-SSC-9674093] PDGFRs bind type I TKI - Sus scrofa
[Reaction:R-BTA-9674093] PDGFRs bind type I TKI - Bos taurus
[Reaction:R-CFA-9674093] PDGFRs bind type I TKI - Canis familiaris
[Reaction:R-RNO-9674093] PDGFRs bind type I TKI - Rattus norvegicus
[Reaction:R-MMU-9674093] PDGFRs bind type I TKI - Mus musculus
output
[Complex:R-HSA-9674082] PDGFR:type I PDGFR-binding TKIs [plasma membrane]
releaseDate
2020年03月17日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9676030] Ip, Carman K M, 2020年02月06日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9674093
summation
[Summation:9674088] Wild-type PDGFRA and PDGFRB can be bound and inhibited by c...
Referrals
(normalReaction)
[Reaction:R-HSA-9674427] PDGFR mutants bind type I TKIs
(hasEvent)
[Pathway:R-HSA-186797] Signaling by PDGF
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