Reactome Pathway Database

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PDGFR mutants bind type I TKIs Show undefined attributes

authored

[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日

category binding

compartment

created [InstanceEdit:9674429] Rothfels, Karen, 2020年01月13日

crossReference

[DatabaseIdentifier:11944892] Mondo:0004992

dbId 9674427

disease

[Disease:1500689] cancer

displayName PDGFR mutants bind type I TKIs

edited

[InstanceEdit:9677035] Rothfels, Karen, 2020年02月25日

entityFunctionalStatus

[EntityFunctionalStatus:9674446] gain_of_function of type I TKI sensitive PDGFR mutants [plasma membrane]

eventOf

[Pathway:R-HSA-9674428] PDGFR mutants bind TKIs - Homo sapiens

input

isChimeric false

isInDisease true

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日

name

PDGFR mutants bind type I TKIs

normalReaction [Reaction:R-HSA-9674093] PDGFRs bind type I TKI

output

[Complex:R-HSA-9674345] type I sensitive PDGFR mutants:type I TKIs [plasma membrane]

releaseDate 2020年03月17日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

[InstanceEdit:9676030] Ip, Carman K M, 2020年02月06日

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-9674427

summation

[Summation:9674504] Avipritinib, crenolanib, pazopanib and other type I tyrosine...

Referrals

(hasEvent)

[Pathway:R-HSA-9674428] PDGFR mutants bind TKIs

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