Reactome | Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies Show undefined attributes

author

[Person:9671889] Ip, CKM
[Person:9671891] Ng, PKS
[Person:9671883] Jeong, KJ
[Person:9671892] Shao, SH
[Person:2404159] Ju, Z
[Person:9671893] Leonard, PG
[Person:9671890] Hua, X
[Person:9671884] Vellano, CP
[Person:9671894] Woessner, R
[Person:9671888] Sahni, N
[Person:9671885] Scott, KL
[Person:2317367] Mills, GB

created [InstanceEdit:9671887] Rothfels, Karen, 2019年12月23日

dbId 9671886

displayName Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

journal Nat Commun

pages 4583

pubMedIdentifier 30389923

schemaClass LiteratureReference

title Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

url http://www.ncbi.nlm.nih.gov/pubmed/30389923

volume 9

year 2018

Referrals

(literatureReference)

[DefinedSet:R-HSA-9674352] sunitinib sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9672129] imatinib-sensitive PDGFR mutants [plasma membrane]
[Reaction:R-HSA-9674427] PDGFR mutants bind type I TKIs
[DefinedSet:R-HSA-9674343] crenolanib-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane]
[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib
[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants
[Reaction:R-HSA-9672159] STAT binds to p-11Y PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672178] PI3-kinase binds to PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672163] SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672173] Autophosphorylation of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672174] Ligand-independent dimerization of PDGFRA extracellular domain mutants
[EntityWithAccessionedSequence:R-HSA-9671971] PDGFRA Y288C [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-HSA-9672027] p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
[Reaction:R-HSA-9672168] Ligand-independent dimerization of PDGFR mutants
[CandidateSet:R-HSA-9672133] transmembrane domain PDGFRA mutants [plasma membrane]
[CandidateSet:R-HSA-9672130] transmembrane domain PDGFRA mutant dimers [plasma membrane]
[CandidateSet:R-HSA-9672075] p-11Y transmembrane domain PDGFRA mutant dimers [plasma membrane]
[Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors

(author)

[Person:9671884] Vellano, CP
[Person:9671885] Scott, KL
[Person:2404159] Ju, Z
[Person:9671883] Jeong, KJ
[Person:9671892] Shao, SH
[Person:9671893] Leonard, PG
[Person:9671894] Woessner, R
[Person:2317367] Mills, GB
[Person:9671888] Sahni, N
[Person:9671889] Ip, CKM
[Person:9671890] Hua, X
[Person:9671891] Ng, PKS

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Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies Show undefined attributes

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