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Schema
>
LiteratureReference
>
Entries
Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
Show undefined attributes
author
[Person:9671889] Ip, CKM
[Person:9671891] Ng, PKS
[Person:9671883] Jeong, KJ
[Person:9671892] Shao, SH
[Person:2404159] Ju, Z
[Person:9671893] Leonard, PG
[Person:9671890] Hua, X
[Person:9671884] Vellano, CP
[Person:9671894] Woessner, R
[Person:9671888] Sahni, N
[Person:9671885] Scott, KL
[Person:2317367] Mills, GB
created
[InstanceEdit:9671887] Rothfels, Karen, 2019年12月23日
dbId
9671886
displayName
Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
journal
Nat Commun
pages
4583
pubMedIdentifier
30389923
schemaClass
LiteratureReference
title
Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies
url
http://www.ncbi.nlm.nih.gov/pubmed/30389923
volume
9
year
2018
Referrals
(literatureReference)
[DefinedSet:R-HSA-9674352] sunitinib sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9672129] imatinib-sensitive PDGFR mutants [plasma membrane]
[Reaction:R-HSA-9674427] PDGFR mutants bind type I TKIs
[DefinedSet:R-HSA-9674343] crenolanib-sensitive PDGFR mutants [plasma membrane]
[DefinedSet:R-HSA-9672125] imatinib-resistant PDGFR mutants [plasma membrane]
[FailedReaction:R-HSA-9674398] D842V PDGFRA doesn't bind sunitinib
[Pathway:R-HSA-9673770] Signaling by PDGFRA extracellular domain mutants
[Reaction:R-HSA-9672159] STAT binds to p-11Y PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672162] PI3K catalyses the phosphorylation of PIP2 to PIP3 downstream of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672178] PI3-kinase binds to PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672163] SOS-mediated nucleotide exchange on RAS downstream of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672158] GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672173] Autophosphorylation of PDGFRA extracellular domain dimers
[Reaction:R-HSA-9672174] Ligand-independent dimerization of PDGFRA extracellular domain mutants
[EntityWithAccessionedSequence:R-HSA-9671971] PDGFRA Y288C [endoplasmic reticulum membrane]
[EntityWithAccessionedSequence:R-HSA-9672027] p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
[Reaction:R-HSA-9672168] Ligand-independent dimerization of PDGFR mutants
[CandidateSet:R-HSA-9672133] transmembrane domain PDGFRA mutants [plasma membrane]
[CandidateSet:R-HSA-9672130] transmembrane domain PDGFRA mutant dimers [plasma membrane]
[CandidateSet:R-HSA-9672075] p-11Y transmembrane domain PDGFRA mutant dimers [plasma membrane]
[Reaction:R-HSA-389083] Autophosphorylation of PDGF alpha receptors
(author)
[Person:9671884] Vellano, CP
[Person:9671885] Scott, KL
[Person:2404159] Ju, Z
[Person:9671883] Jeong, KJ
[Person:9671892] Shao, SH
[Person:9671893] Leonard, PG
[Person:9671894] Woessner, R
[Person:2317367] Mills, GB
[Person:9671888] Sahni, N
[Person:9671889] Ip, CKM
[Person:9671890] Hua, X
[Person:9671891] Ng, PKS
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