Reactome Pathway Database

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Schema > Disease > Entries

breast cancer Show undefined attributes

created [InstanceEdit:1500574] Orlic-Milacic, Marija, 2011年08月19日

databaseName DOID

dbId 1500576

definition A thoracic cancer that originates in the mammary gland.

displayName breast cancer

identifier 1612

name

breast cancer

referenceDatabase [ReferenceDatabase:1247631] DOID

schemaClass Disease

synonym

malignant tumor of the breast
mammary cancer
malignant neoplasm of breast
mammary tumor
primary breast cancer
breast cancer
Ca breast - NOS
breast tumor

url https://www.ebi.ac.uk/ols/ontologies/doid/terms?obo_id=DOID:1612

Referrals

(disease)

[ChemicalDrug:R-ALL-9716874] TAM [nucleoplasm]
[ChemicalDrug:R-ALL-9716883] fulvestrant [nucleoplasm]
[ChemicalDrug:R-ALL-9716900] raloxifene [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9632461] p16INK4A D84G [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632586] p16INK4A R80* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632582] p16INK4A R58* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9630911] p16INK4A M53I [cytosol]
[EntityWithAccessionedSequence:R-HSA-9632280] p16INK4A P81L [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648383] p16INK4A S12* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648397] p16INK4A E69* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9631308] p16INK4A G35V [cytosol]
[EntityWithAccessionedSequence:R-HSA-9724169] PALB2 Y28C [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724168] PALB2 L35P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724172] PALB2 L24S [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724178] PALB2 R37H [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724554] PALB2 L947F [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724584] PALB2 G1043D [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704424] PALB2 T1030I [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704749] PALB2 T841Qfs*10 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724589] PALB2 L1119P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724557] PALB2 L947S [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704428] PALB2 L1143P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724556] PALB2 L1070P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704738] PALB2 C77Vfs*100 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704417] PALB2 L939W [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724583] PALB2 L961P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724551] PALB2 W912G [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704442] PALB2 L531Cfs*30 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724569] PALB2 G1043A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724563] PALB2 W1140G [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724592] PALB2 G937R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724567] PALB2 I944N [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724649] PALB2 G1121Vfs*3 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724654] PALB2 G1166Vfs*25 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724644] PALB2 Y1108Sfs*16 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704821] PALB2 N1039Ifs*2 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704820] PALB2 A995Cfs*16 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724623] PALB2 E230* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724620] PALB2 Q251* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724635] PALB2 E669Gfs*3 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724634] PALB2 D715Efs*2 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724639] PALB2 C882Wfs*3 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704790] PALB2 Y1183* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724587] PALB2 I1037T [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9704483] PALB2 Y409* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724594] PALB2 L1172P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724559] PALB2 L972Q [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9724561] PALB2 G1043C [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9702140] BRCA1 M1411T [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9701202] BRCA1 M1400V [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9702135] BRCA1 L1407P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700907] BRCA1 C64R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700890] BRCA1 C61G [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700938] BRCA1 C39Y [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700921] BRCA1 H41R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9663198] BRCA1 C24R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700927] BRCA1 H41A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700911] BRCA1 M18T [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700941] BRCA1 C47G [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700899] BRCA1 C64G [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700944] BRCA1 C44F [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700934] BRCA1 T37R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700916] BRCA1 C27A [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700959] BRCA1 E23Afs*18 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700894] BRCA1 C61Y [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700960] BRCA1 E23Rfs*18 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9700967] BRCA1 E23Vfs*17 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9709538] BRCA2 D2983Ffs*34 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9709557] BRCA2 F2058Lfs*12 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9709627] BRCA2 G25R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9709625] BRCA2 W31C [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9709628] BRCA2 W31R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9709629] BRCA2 G25V [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9726075] TP53 L344P [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9726073] TP53 L344R [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9726101] TP53 R342P [nucleoplasm]
[BlackBoxEvent:R-HSA-9710490] The GSDME gene promoter is hypermethylated
[EntityWithAccessionedSequence:R-HSA-9710426] hyper 5-mC GSDME gene promoter [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9673079] DAXX C106* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9670961] ATRX E63* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9671579] ATRX Q193* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9672298] ATRX G859Rfs*4 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9671254] ATRX S750* [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9672244] ATRX L359Tfs*3 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9659801] RB1 R661W [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9659812] RB1 C706F [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-9661769] RB1 W99* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662241] RB1 S463* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662213] RB1 R467* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662237] RB1 S576* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662226] RB1 S829* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688046] RB1 K143Mfs*19 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9689579] RB1 W195* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688039] RB1 L343Sfs*3 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688033] RB1 S318* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688008] RB1 P253Gfs*5 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688009] RB1 S360Pfs*2 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688010] RB1 E323Kfs*9 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688007] RB1 K417Wfs*23 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661889] RB1 R255* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661377] RB1 K4* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688025] RB1 I66Yfs*11 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661913] RB1 Q257* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688018] RB1 E72Vfs*34 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661866] RB1 S215* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661876] RB1 S230* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9687990] RB1 S842* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662573] RB1 E843* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662574] RB1 E464* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662566] RB1 E747* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661542] RB1 E79* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688160] RB1 C102Yfs*7 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661536] RB1 E97* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688163] RB1 L542Kfs*11 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688188] RB1 F482Sfs*10 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662540] RB1 E837* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662542] RB1 E440* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688131] RB1 P232Rfs*4 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662558] RB1 E693* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688148] RB1 E837Dfs*12 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688151] RB1 G617Rfs*36 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688102] RB1 R418Sfs*9 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688103] RB1 A74Efs*4 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688127] RB1 F104Lfs*7 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688114] RB1 L486Ifs*6 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688115] RB1 S565* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688072] RB1 P777Lfs*33 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662474] RB1 Q850* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688065] RB1 Y771Cfs*23 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662488] RB1 Q471* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688080] RB1 R73Sfs*36 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660655] RB1 Q395* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660640] RB1 R251* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660668] RB1 Q217* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662203] RB1 S838* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660661] RB1 R556* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660637] RB1 R552* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660632] RB1 R455* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9660630] RB1 R320* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662143] RB1 E364* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9662131] RB1 E315* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9688201] RB1 D346Vfs*17 [cytosol]
[EntityWithAccessionedSequence:R-HSA-9661042] RB1 T738_R775del [nucleoplasm]
[ChemicalDrug:R-ALL-9707338] exemestane [cytosol]
[ChemicalDrug:R-ALL-9707320] anastrozole [cytosol]
[ChemicalDrug:R-ALL-9707326] testolactone [cytosol]
[ChemicalDrug:R-ALL-9707331] letrozole [cytosol]
[ChemicalDrug:R-ALL-9707334] fadrozole [cytosol]
[ChemicalDrug:R-ALL-9707317] aminoglutethimide [cytosol]
[EntityWithAccessionedSequence:R-HSA-1173212] EGFR L858R [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1181211] EGFR E746_A750del [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9678440] SMAD4 G473* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675625] SMAD4 S144* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675626] SMAD4 E538* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675621] SMAD4 S154* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675641] SMAD4 S343* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675177] SMAD4 Q289* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675175] SMAD4 Q245* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675168] SMAD4 Q224* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675199] SMAD4 Q83* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675065] SMAD4 R445* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675191] SMAD4 Q334* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9675648] SMAD4 E526* [cytosol]
[EntityWithAccessionedSequence:R-HSA-2399540] PIK3R1 R574T [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1500714] PIK3CA H1047L [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500716] PIK3CA H1047R [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500719] PIK3CA M1043I [cytosol]
[EntityWithAccessionedSequence:R-HSA-2395932] PIK3CA M1043V [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500720] PIK3CA H1047Y [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500701] PIK3CA E542K [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500705] PIK3CA Q546K [cytosol]
[EntityWithAccessionedSequence:R-HSA-2362355] PIK3CA E545A [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500706] PIK3CA E545K [cytosol]
[EntityWithAccessionedSequence:R-HSA-2362362] PIK3CA E545Q [cytosol]
[EntityWithAccessionedSequence:R-HSA-2362383] PIK3CA Q546E [cytosol]
[EntityWithAccessionedSequence:R-HSA-2328074] PIK3CA E542V [cytosol]
[EntityWithAccessionedSequence:R-HSA-2362375] PIK3CA Q546L [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500709] PIK3CA E545G [cytosol]
[EntityWithAccessionedSequence:R-HSA-2362373] PIK3CA Q546R [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500695] PIK3CA Q546P [cytosol]
[EntityWithAccessionedSequence:R-HSA-2328003] PIK3CA E542Q [cytosol]
[EntityWithAccessionedSequence:R-HSA-1500718] PIK3CA R38H [cytosol]
[EntityWithAccessionedSequence:R-HSA-2399994] p-T308,S473-AKT1 E17K [nucleoplasm]
[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant
[Complex:R-HSA-2243941] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2243935] p-T308,S473-AKT1 E17K [cytosol]
[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2
[EntityWithAccessionedSequence:R-HSA-2219526] AKT1 E17K [cytosol]
[Reaction:R-HSA-2243938] AKT1 E17K mutant is phosphorylated by TORC2 complex
[Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2243944] p-S473-AKT1 E17K [plasma membrane]
[Complex:R-HSA-2219527] AKT1 E17K mutant:PIP2 [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1500573] AKT1 E17K [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-2317430] PTEN R130L [cytosol]
[EntityWithAccessionedSequence:R-HSA-2317416] PTEN R130Q [cytosol]
[EntityWithAccessionedSequence:R-HSA-2317432] PTEN R130P [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659052] PTEN E99* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659305] PTEN Q17* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659360] PTEN S59* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659320] PTEN Q149* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659387] PTEN Y46* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659189] PTEN L182* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659312] PTEN Q171* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659400] PTEN Y68* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659399] PTEN Y88* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659032] PTEN E40* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659414] PTEN W111* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659152] PTEN K13* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659409] PTEN Y174* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659371] PTEN S287* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659302] PTEN Q219* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659303] PTEN Q261* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659388] PTEN Y336* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659326] PTEN Q245* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659314] PTEN Q298* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659392] PTEN Y346* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659393] PTEN W274* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659098] PTEN E256* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659029] PTEN E235* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9659159] PTEN K344* [cytosol]
[EntityWithAccessionedSequence:R-HSA-9665342] ERBB2 G309E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665349] ERBB2 G309A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665350] ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665344] ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665381] p-6Y-ERBB2 G309A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665382] p-6Y-ERBB2 G309E [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665379] p-6Y-ERBB2 S310F [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665385] p-6Y-ERBB2 S310Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654303] p-Y-ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654695] p-Y-ERBB2 T862A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654833] p-Y-ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654401] p-Y-ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654194] p-Y-ERBB2 L755S [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654398] p-Y-ERBB2 V777M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654191] p-Y-ERBB2 L755M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654193] p-Y-ERBB2 L755W [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654730] p-Y-ERBB2 L869R [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9664602] p-Y-ERBB2 G776V [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646620] ERBB2 D769Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646703] ERBB2 V842I [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646824] ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646617] ERBB2 D769H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9649434] ERBB2 T862A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646423] ERBB2 L755S [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646737] ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646579] ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646591] ERBB2 V777M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646516] ERBB2 L755W [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646517] ERBB2 L755M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646714] ERBB2 R896C [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646667] ERBB2 G778_P780dup [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9646827] ERBB2 L869R [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9664450] ERBB2 G776V [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647214] p-6Y-ERBB2 V777L [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647215] p-6Y-ERBB2 H878Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9663599] ERBB2 L755_T759del [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647208] p-6Y-ERBB2 R896C [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647209] p-6Y-ERBB2 V842I [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647211] p-6Y-ERBB2 I767M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9654692] p-6Y-ERBB2 T862A [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647200] p-6Y-ERBB2 D769H [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647198] p-6Y-ERBB2 G778_P780dup [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647216] p-6Y-ERBB2 L755S [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647199] p-6Y-ERBB2 D769Y [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647204] p-6Y-ERBB2 L755M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647205] p-6Y-ERBB2 V777M [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9647201] p-6Y-ERBB2 L755W [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665871] p-6Y-ERBB2 E693K [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665756] ERBB2 R678Q [plasma membrane]
[Complex:R-HSA-190228] FGFR1b homodimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9656603] HRAS K117N [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9652799] p-T185,Y187 MAPK1 E81K [cytosol]
[EntityWithAccessionedSequence:R-HSA-9648633] p-BRAF G464V [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9648611] BRAF G464V [cytosol]
[ChemicalDrug:R-ALL-9695935] ROMe [cytosol]
[ChemicalDrug:R-ALL-9838650] TAM [endoplasmic reticulum lumen]
[ChemicalDrug:R-ALL-9705892] nandrolone [cytosol]
[ChemicalDrug:R-ALL-9705920] dromostanolone propionate [cytosol]
[ChemicalDrug:R-ALL-9705902] nandrolone decanoate [cytosol]
[ChemicalDrug:R-ALL-9705899] fluoxymesterone [cytosol]
[EntityWithAccessionedSequence:R-HSA-8853122] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-p-8Y-FGFR1(1-822) [plasma membrane]
[Complex:R-HSA-8853166] ERLIN2(1-185):p-8Y FGFR1(c.-88-822) fusion dimer [plasma membrane]
[DefinedSet:R-HSA-1982053] Overexpressed FGFR1 homodimers [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853148] EML4(1-186)insVSLKRRIELTVEYPWRCGALSPTSNCRTG-FGFR1(1-822) [plasma membrane]
[Complex:R-HSA-8853164] ERLIN2(1-185):FGFR1(c.-88->(-1)) fusion dimer [plasma membrane]
[Complex:R-HSA-2029932] p-6Y-FGFR2b C3 variant dimer [plasma membrane]
[Complex:R-HSA-2029916] Activated overexpressed FGFR2 [plasma membrane]
[DefinedSet:R-HSA-2029940] Activated overexpressed FGFR2 dimers [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853133] p-6Y-FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
[Complex:R-HSA-8853221] p-6Y FGFR2(22-767)-CASP7(1-303) fusion dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853130] p-6Y-FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
[Complex:R-HSA-8853216] p-6Y FGFR2(22-767)-AFF3(292-1226) fusion dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853134] p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
[Complex:R-HSA-8853224] p-6Y FGFR2(22-767)-CCDC6(102-474) fusion dimer [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853139] FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853153] FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-8853137] FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
[Complex:R-HSA-8853174] FGFR2(22-767)-AFF3(292-1226) fusion dimer [plasma membrane]
[Complex:R-HSA-8853179] FGFR2(22-767)-CASP7(1-303) fusion dimer [plasma membrane]
[Complex:R-HSA-8853182] FGFR2(22-767)-CCDC6(102-474) fusion dimer [plasma membrane]
[Complex:R-HSA-2029938] Overexpressed FGFR2 dimer [plasma membrane]
[DefinedSet:R-HSA-2029963] Overexpressed FGFR2 homodimers [plasma membrane]
[Complex:R-HSA-2029966] Overexpressed FGFR2:TKIs [plasma membrane]
[Reaction:R-HSA-2029992] Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants
[Reaction:R-HSA-2029989] Autocatalytic phosphorylation of overexpressed FGFR2 variants
[EntityWithAccessionedSequence:R-HSA-2011873] p5Y-FGFR4 Y367C mutant [plasma membrane]
[Complex:R-HSA-2011990] Activated FGFR4 Y367C mutant [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-1614439] FGFR4 Y367C [plasma membrane]
[Complex:R-HSA-2011955] FGFR4 Y367C mutant dimer [plasma membrane]
[Reaction:R-HSA-2012086] Constitutive dimerization of FGFR4 Y367C mutant
[Reaction:R-HSA-2012087] Autocatalytic phosphorylation of FGFR4 Y367C mutant
[EntityWithAccessionedSequence:R-HSA-5339694] LRP5 D666_L809del [plasma membrane]
[FailedReaction:R-HSA-5339711] misspliced mutants of LRP5 support enhanced beta-catenin-dependent signaling
[Pathway:R-HSA-5339717] Signaling by LRP5 mutants
[EntityWithAccessionedSequence:R-HSA-9706638] CBL H398R [cytosol]
[EntityWithAccessionedSequence:R-HSA-9665876] p-6Y-ERBB2 R678Q [plasma membrane]
[EntityWithAccessionedSequence:R-HSA-9665761] ERBB2 E693K [plasma membrane]

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