Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

TP53 L344P [nucleoplasm] Show undefined attributes

compartment

[Compartment:7660] nucleoplasm

created [InstanceEdit:9726067] Orlic-Milacic, Marija, 2021年04月05日

crossReference

dbId 9726075

disease

displayName TP53 L344P [nucleoplasm]

endCoordinate 393

hasModifiedResidue

[ReplacedResidue:9726069] L-leucine 344 replaced with L-proline

inDisease true

literatureReference

[LiteratureReference:9726064] Folding of tetrameric p53: oligomerization and tumorigenic mutations induce misfolding and loss of function
[LiteratureReference:9726103] p53 mutants without a functional tetramerisation domain are not oncogenic
[LiteratureReference:9726245] Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome
[LiteratureReference:9726252] Oligomerization is not essential for growth suppression by p53 in p53-deficient osteosarcoma Saos-2 cells
[LiteratureReference:9726286] Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members
[LiteratureReference:9726293] Characterization of p53 mutants identified in human tumors with a missense mutation in the tetramerization domain
[LiteratureReference:9726313] Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation

maxDepth 1

memberOf

[CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm] - Homo sapiens

modified [InstanceEdit:9726317] Orlic-Milacic, Marija, 2021年04月06日

name

TP53 L344P

referenceEntity [ReferenceGeneProduct:uniprot:P04637] UniProt:P04637 TP53

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-9726075

startCoordinate 1

Referrals

(hasMember)

[CandidateSet:R-HSA-9720037] TP53 mutants (tetramerization) [nucleoplasm]

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