Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

PIK3CA E542K [cytosol] Show undefined attributes

compartment

[Compartment:70101] cytosol

created [InstanceEdit:1500696] Orlic-Milacic, Marija, 2011年08月19日

crossReference

dbId 1500701

disease

displayName PIK3CA E542K [cytosol]

endCoordinate 1068

hasModifiedResidue

[ReplacedResidue:1500700] L-glutamic acid 542 replaced with L-lysine

inDisease true

literatureReference

[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers
[LiteratureReference:2399592] Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit
[LiteratureReference:2399617] Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells

maxDepth 1

memberOf

[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol] - Homo sapiens

modified [InstanceEdit:5696640] Matthews, Lisa, 2015年05月29日

name

PIK3CA E542K
PIK3CA Glu542Lys

referenceEntity [ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1500701

startCoordinate 1

summation

[Summation:2399583] Substitution of glutamic acid residue at position 542 of PIK...

updateTrackers

[UpdateTracker:9888232] Update Tracker - [EntityWithAccessionedSequence:1500701] PIK3CA E542K [cytosol] - v46:[modifyName]

Referrals

(hasMember)

[CandidateSet:R-HSA-2399587] PIK3CA helical domain mutants [cytosol]

(updatedInstance)

[UpdateTracker:9888232] Update Tracker - [EntityWithAccessionedSequence:1500701] PIK3CA E542K [cytosol] - v46:[modifyName]

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