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Schema
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Reaction
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Entries
PDPK1 phosphorylates AKT1 E17K mutant
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authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
catalystActivity
[CatalystActivity:2243940] protein serine/threonine kinase activity of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:2243934] Orlic-Milacic, M, 2012年05月09日
crossReference
[DatabaseIdentifier:11944899] Mondo:0005575
[DatabaseIdentifier:11944895] Mondo:0007254
[DatabaseIdentifier:11944896] Mondo:0008170
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2243942
disease
[Disease:1500576] breast cancer
[Disease:1500689] cancer
[Disease:1248674] large intestine cancer
[Disease:1500575] ovarian cancer
displayName
PDPK1 phosphorylates AKT1 E17K mutant
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
entityFunctionalStatus
[EntityFunctionalStatus:3080614] gain_of_function of PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
eventOf
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
followingEvent
[Reaction:R-HSA-2399966] AKT1 E17K mutant phosphorylates GSK3 - Homo sapiens
[Reaction:R-HSA-2399985] AKT1 E17K mutant phosphorylates caspase-9 - Homo sapiens
[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) - Homo sapiens
[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - Homo sapiens
[Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2 - Homo sapiens
[Reaction:R-HSA-2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha) - Homo sapiens
[Reaction:R-HSA-2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1 - Homo sapiens
[Reaction:R-HSA-2399941] AKT1 E17K mutant phosphorylates BAD - Homo sapiens
input
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[Complex:R-HSA-2243941] PDPK1:p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
[LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
[LiteratureReference:2219518] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
PDPK1 phosphorylates AKT1 E17K mutant
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[EntityWithAccessionedSequence:R-HSA-2243935] p-T308,S473-AKT1 E17K [cytosol]
[Complex:R-HSA-2219520] PDPK1:PIP2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2243942
summation
[Summation:2243936] PIP2-bound AKT1 E17K mutant is constitutively phosphorylated...
Referrals
(precedingEvent)
[Reaction:R-HSA-2399966] AKT1 E17K mutant phosphorylates GSK3
[Reaction:R-HSA-2399985] AKT1 E17K mutant phosphorylates caspase-9
[Reaction:R-HSA-2399997] AKT1 E17K mutant translocates to the nucleus
[Reaction:R-HSA-2399977] AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)
[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it
[Reaction:R-HSA-2399981] AKT1 E17K mutant phosphorylates MDM2
[Reaction:R-HSA-2400001] AKT1 E17K mutant phosphorylates CHUK (IKKalpha)
[Reaction:R-HSA-2399969] AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1
[Reaction:R-HSA-2399941] AKT1 E17K mutant phosphorylates BAD
(hasEvent)
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer
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