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Schema
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Reaction
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Entries
AKT1 E17K mutant phosphorylates TSC2, inhibiting it
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authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
catalystActivity
[CatalystActivity:2399974] protein serine/threonine kinase activity of p-T308,S473-AKT1 E17K [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:2399979] Orlic-Milacic, M, 2012年07月13日
crossReference
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2399982
disease
[Disease:1500689] cancer
displayName
AKT1 E17K mutant phosphorylates TSC2, inhibiting it
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
entityFunctionalStatus
[EntityFunctionalStatus:2400002] gain_of_function of p-T308,S473-AKT1 E17K [cytosol]
eventOf
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
input
2 ×
[SimpleEntity:R-ALL-113592] ATP [cytosol]
[EntityWithAccessionedSequence:R-HSA-2980548] TSC2 [cytosol]
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:199381] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
[LiteratureReference:199857] Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
AKT1 E17K mutant phosphorylates TSC2, inhibiting it
normalReaction
[Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it
output
2 ×
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[EntityWithAccessionedSequence:R-HSA-199484] p-S939,T1462-TSC2 [cytosol]
precedingEvent
[Reaction:R-HSA-2243942] PDPK1 phosphorylates AKT1 E17K mutant - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2399982
summation
[Summation:2399980] AKT1 E17K gain-of-function mutant is expected to phosphoryla...
updateTrackers
[UpdateTracker:9787553] Update Tracker - [Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
Referrals
(updatedInstance)
[UpdateTracker:9787553] Update Tracker - [Reaction:2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it - v44:[add_removeInput]
(hasEvent)
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer
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