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AKT phosphorylates TSC2, inhibiting it Show undefined attributes

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authored

[InstanceEdit:188342] Nasi, Sergio, Annibali, D, 2006年10月10日

catalystActivity

[CatalystActivity:198368] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:198616] Jassal, B, 2007年06月29日 07:57:48

dbId 198609

displayName AKT phosphorylates TSC2, inhibiting it

edited

[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014年12月23日

eventOf

followingEvent

[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens

goBiologicalProcess [GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction

input

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

name

AKT phosphorylates TSC2, inhibiting it

orthologousEvent

output

precedingEvent

[Reaction:R-HSA-198270] PDPK1 phosphorylates AKT at T308 - Homo sapiens

releaseDate 2008年03月12日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-198609

summation

[Summation:199479] AKT phosphorylates and inhibits TSC2 (tuberin), a suppressor...

updateTrackers

Referrals

(updatedInstance)

(normalReaction)

[Reaction:R-HSA-2399982] AKT1 E17K mutant phosphorylates TSC2, inhibiting it

(hasEvent)

(precedingEvent)

[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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