Reactome Pathway Database

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AKT phosphorylates TSC2, inhibiting it Show undefined attributes

catalystActivity

[CatalystActivity:10792468] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

category transition

compartment

[Compartment:70101] cytosol

created [InstanceEdit:10778922] Weiser, Joel, 2025年08月27日

dbId 10792470

displayName AKT phosphorylates TSC2, inhibiting it

eventOf

[Pathway:R-DME-198323] AKT phosphorylates targets in the cytosol - Drosophila melanogaster
[Pathway:R-DME-5628897] TP53 Regulates Metabolic Genes - Drosophila melanogaster

evidenceType [EvidenceType:9965817] inferred by electronic annotation

followingEvent

[Reaction:R-DME-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Drosophila melanogaster

goBiologicalProcess [GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction

inferredFrom

[Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

AKT phosphorylates TSC2, inhibiting it

output

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:56210] Drosophila melanogaster

stId R-DME-198609

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

(precedingEvent)

[Reaction:R-DME-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

(inferredTo)

[Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it

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