Reactome Pathway Database

Schema > Reaction > Entries

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 Show undefined attributes

authored

[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014年12月23日

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:5632733] Orlic-Milacic, Marija, 2014年10月28日

dbId 5632732

displayName p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

edited

[InstanceEdit:5659776] Orlic-Milacic, Marija, 2014年12月23日

eventOf

[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes - Homo sapiens

input

isChimeric false

isInDisease false

isInferred false

literatureReference

maxDepth 1

modified [InstanceEdit:11001822] Weiser, Joel, 2025年08月28日

name

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

orthologousEvent

output

[Complex:R-HSA-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol]

precedingEvent

[Reaction:R-HSA-198609] AKT phosphorylates TSC2, inhibiting it - Homo sapiens

regulatedBy

[NegativeRegulation:R-HSA-5632745] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]'

regulationReference

[RegulationReference:9642283] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]' p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage

releaseDate 2015年03月19日

reviewStatus [ReviewStatus:9821382] five stars

reviewed

schemaClass Reaction

species

[Species:48887] Homo sapiens

stId R-HSA-5632732

summation

[Summation:5632729] Phosphorylation of TSC2 by AKT enables association of TSC2 w...

Referrals

(hasEvent)

[Pathway:R-HSA-5628897] TP53 Regulates Metabolic Genes

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