Reactome Pathway Database

Schema > Reaction > Entries

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 Show undefined attributes

category binding

compartment

[Compartment:70101] cytosol

created [InstanceEdit:9965813] Weiser, Joel, 2025年08月27日

dbId 10039863

displayName p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

eventOf

[Pathway:R-MMU-5628897] TP53 Regulates Metabolic Genes - Mus musculus

evidenceType [EvidenceType:9965817] inferred by electronic annotation

inferredFrom

[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens

input

isInDisease false

isInferred true

maxDepth 1

name

p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

output

[Complex:R-MMU-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol]

precedingEvent

[Reaction:R-MMU-198609] AKT phosphorylates TSC2, inhibiting it - Mus musculus

regulatedBy

[NegativeRegulation:10039864] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]'

releaseDate 2025年09月18日

schemaClass Reaction

species

[Species:48892] Mus musculus

stId R-MMU-5632732

summation

[Summation:9965816] This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)

[Pathway:R-MMU-5628897] TP53 Regulates Metabolic Genes

(inferredTo)

[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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