Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

AKT1 E17K [cytosol] Show undefined attributes

candidateOf

[CandidateSet:R-HSA-2400013] AKT/AKT1 E17K mutant [cytosol] - Homo sapiens

compartment

[Compartment:70101] cytosol

consumedByEvent

[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens

created [InstanceEdit:2219531] Orlic-Milacic, M, 2012年05月01日

crossReference

dbId 2219526

disease

displayName AKT1 E17K [cytosol]

endCoordinate 480

hasModifiedResidue

[ReplacedResidue:1500572] L-glutamic acid 17 replaced with L-lysine

inDisease true

literatureReference

[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

maxDepth 1

modified [InstanceEdit:3662293] Orlic-Milacic, M, 2013年06月06日

name

AKT1 E17K
AKT1 Glu17Lys

referenceEntity [ReferenceGeneProduct:uniprot:P31749] UniProt:P31749 AKT1

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-2219526

startCoordinate 1

updateTrackers

[UpdateTracker:9887822] Update Tracker - [EntityWithAccessionedSequence:2219526] AKT1 E17K [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)

[UpdateTracker:9887822] Update Tracker - [EntityWithAccessionedSequence:2219526] AKT1 E17K [cytosol] - v46:[modifyName]

(hasCandidate)

[CandidateSet:R-HSA-2400013] AKT/AKT1 E17K mutant [cytosol]

(input)

[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2

(diseaseEntity)

[EntityFunctionalStatus:2362350] gain_of_function of AKT1 E17K [cytosol]

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