Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Reaction
>
Entries
AKT1 E17K mutant is phosphorylated by TORC2 complex
Show undefined attributes
Go to Details
authored
[InstanceEdit:2422427] Orlic-Milacic, M, 2012年07月18日
catalystActivity
[CatalystActivity:198624] protein serine/threonine kinase activity of TORC2 complex [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created
[InstanceEdit:2243934] Orlic-Milacic, M, 2012年05月09日
crossReference
[DatabaseIdentifier:11944899] Mondo:0005575
[DatabaseIdentifier:11944896] Mondo:0008170
[DatabaseIdentifier:11944895] Mondo:0007254
[DatabaseIdentifier:11944892] Mondo:0004992
dbId
2243938
disease
[Disease:1500689] cancer
[Disease:1500576] breast cancer
[Disease:1248674] large intestine cancer
[Disease:1500575] ovarian cancer
displayName
AKT1 E17K mutant is phosphorylated by TORC2 complex
edited
[InstanceEdit:2426555] Matthews, L, 2012年08月03日
entityFunctionalStatus
[EntityFunctionalStatus:3080617] gain_of_function of AKT1 E17K mutant:PIP2 [plasma membrane]
eventOf
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer - Homo sapiens
followingEvent
[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1 - Homo sapiens
input
[Complex:R-HSA-2219527] AKT1 E17K mutant:PIP2 [plasma membrane]
[SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric
false
isInDisease
true
isInferred
false
literatureReference
[LiteratureReference:1500571] A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
[LiteratureReference:2219532] Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023年03月08日
name
AKT1 E17K mutant is phosphorylated by TORC2 complex
output
[SimpleEntity:R-ALL-29370] ADP [cytosol]
[Complex:R-HSA-2243943] p-S473-AKT1 E17K mutant:PIP2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-2219536] AKT1 E17K mutant binds PIP2 - Homo sapiens
releaseDate
2012年09月18日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:2463860] Thorpe, Lauren, 2012年08月13日
[InstanceEdit:2463859] Yuzugullu, Haluk, 2012年08月13日
[InstanceEdit:2463854] Zhao, Jean J, 2012年08月13日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-2243938
summation
[Summation:2243939] PIP2-binding AKT1 E17K mutants are anchored to the plasma m...
Referrals
(precedingEvent)
[Reaction:R-HSA-2243937] PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
(hasEvent)
[Pathway:R-HSA-5674400] Constitutive Signaling by AKT1 E17K in Cancer
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル