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Search ...
Go!
Schema
>
EntityWithAccessionedSequence
>
Entries
p-6Y-ERBB2 V777M [plasma membrane]
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candidateOf
[CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane] - Homo sapiens
[CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane] - Homo sapiens
compartment
[Compartment:876] plasma membrane
created
[InstanceEdit:9647197] Orlic-Milacic, Marija, 2019年05月30日
crossReference
[DatabaseIdentifier:11944899] Mondo:0005575
[DatabaseIdentifier:11944928] Mondo:0001056
[DatabaseIdentifier:11945164] Mondo:0004986
[DatabaseIdentifier:11944895] Mondo:0007254
[DatabaseIdentifier:11944892] Mondo:0004992
[DatabaseIdentifier:9646590] COSMIC:COSV54069186
[DatabaseIdentifier:9646592] COSMIC:COSM4775193
dbId
9647205
disease
[Disease:1500576] breast cancer
[Disease:1500689] cancer
[Disease:1248674] large intestine cancer
[Disease:1500687] stomach cancer
[Disease:1493885] bladder carcinoma
displayName
p-6Y-ERBB2 V777M [plasma membrane]
endCoordinate
1255
hasModifiedResidue
[ReplacedResidue:9646587] L-valine 777 replaced with L-methionine
[ModifiedResidue:1248700] O4'-phospho-L-tyrosine at 1023
[ModifiedResidue:1248685] O4'-phospho-L-tyrosine at 1139
[ModifiedResidue:1248708] O4'-phospho-L-tyrosine at 1196
[ModifiedResidue:1248692] O4'-phospho-L-tyrosine at 1221
[ModifiedResidue:1248701] O4'-phospho-L-tyrosine at 1222
[ModifiedResidue:1248689] O4'-phospho-L-tyrosine at 1248
inDisease
true
literatureReference
[LiteratureReference:9647018] Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies
[LiteratureReference:9647024] Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas
[LiteratureReference:9646931] Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
maxDepth
1
name
p-6Y-ERBB2 V777M
p-6Y-HER2 V777M
p-6Y-ERBB2 Val777Met
p-6Y-HER2 Val777Met
referenceEntity
[ReferenceGeneProduct:uniprot:P04626] UniProt:P04626 ERBB2
referenceType
ReferenceGeneProduct
schemaClass
EntityWithAccessionedSequence
species
[Species:48887] Homo sapiens
stId
R-HSA-9647205
startCoordinate
23
Referrals
(hasCandidate)
[CandidateSet:R-HSA-9665035] p-6Y-ERBB2 KD mutants (EGFR,PLCG1) [plasma membrane]
[CandidateSet:R-HSA-9664920] p-6Y-ERBB2 KD mutants (EGFR,PI3K) [plasma membrane]
[CandidateSet:R-HSA-9664610] p-6Y-ERBB2 KD mutants (EGFR,ERBB3) [plasma membrane]
[CandidateSet:R-HSA-9664999] p-6Y-ERBB2 KD mutants (EGFR,RAS) [plasma membrane]
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