Reactome Pathway Database

Schema > EntityWithAccessionedSequence > Entries

PIK3CA H1047L [cytosol] Show undefined attributes

compartment

[Compartment:70101] cytosol

created [InstanceEdit:1500696] Orlic-Milacic, Marija, 2011年08月19日

crossReference

dbId 1500714

disease

displayName PIK3CA H1047L [cytosol]

endCoordinate 1068

hasModifiedResidue

[ReplacedResidue:1500713] L-histidine 1047 replaced with L-leucine

inDisease true

literatureReference

[LiteratureReference:1500710] High frequency of mutations of the PIK3CA gene in human cancers
[LiteratureReference:2399562] The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations
[LiteratureReference:2399642] Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

maxDepth 1

memberOf

[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol] - Homo sapiens

modified [InstanceEdit:3662293] Orlic-Milacic, M, 2013年06月06日

name

PIK3CA H1047L
PIK3CA His1047Leu

referenceEntity [ReferenceGeneProduct:uniprot:P42336] UniProt:P42336 PIK3CA

referenceType ReferenceGeneProduct

schemaClass EntityWithAccessionedSequence

species [Species:48887] Homo sapiens

stId R-HSA-1500714

startCoordinate 1

summation

[Summation:2399645] Substitution of histidine residue with leucine at position 1...

updateTrackers

[UpdateTracker:9888279] Update Tracker - [EntityWithAccessionedSequence:1500714] PIK3CA H1047L [cytosol] - v46:[modifyName]

Referrals

(updatedInstance)

[UpdateTracker:9888279] Update Tracker - [EntityWithAccessionedSequence:1500714] PIK3CA H1047L [cytosol] - v46:[modifyName]

(hasMember)

[CandidateSet:R-HSA-2399596] PIK3CA kinase domain mutants [cytosol]

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