MOD_CAAXbox

Accession:	ELME000059
Functional site class:	CAAX Box
Functional site description:	Prenyl groups are attached to a Cys residue 4 residues preceding the C-terminus of certain proteins directed to the plasma membrane
ELM Description:	Generic CAAX box prenylation motif. Recognised by Farnesyltransferase and Geranylgeranyltransferase I for transfer of lipophilic units to one or more C-terminal Cys residues.
Pattern:	`(C)[^DENQ][LIVMF].$`
Pattern Probability:	`0.0000024`
Present in taxon:	Eukaryota
Interaction Domain:	PPTA (PF01239) Protein prenyltransferase alpha subunit repeat (Stochiometry: 1 : 1) PDB Structure: 1TNZ

o See 17 Instances for MOD_CAAXbox

o Abstract

Protein prenyltransferases recognise an exposed Cys residue preceding the C-terminus of certain protein substrates. The enzymes covalently attach a prenyl group (farnesyl or geranyl-geranyl) to the Cys residue with the consequence that the (soluble) protein is attached to the membrane. Examples of CAAX box proteins include the Ras-like proteins and the G-protein gamma and (some alpha) subunits. Some effectors of bacterial pathogens also have CAAX boxes which are modified, directing the effector proteins to the membrance.

o 8 GO-Terms:

Biological Process:
Protein Geranylgeranylation (also annotated in class: )
Protein Amino Acid Prenylation (also annotated in class: )
Protein Farnesylation (also annotated in class: )
Protein Prenylation (also annotated in class: )
Cellular Compartment:
Cytosol (also annotated in these classes: CLV_C14_Caspase3-7 CLV_Separin_Fungi CLV_Separin_Metazoa DEG_APCC_DBOX_1 DEG_APCC_KENBOX_2 DEG_APCC_TPR_1 DEG_Cend_DCAF12_1 DEG_Cend_FEM1AC_1 DEG_Cend_FEM1B_2 DEG_Cend_KLHDC2_1 DEG_Cend_TRIM7_1 DEG_COP1_1 DEG_CRBN_cyclicCter_1 DEG_Kelch_actinfilin_1 DEG_Kelch_Keap1_1 DEG_Kelch_Keap1_2 DEG_Kelch_KLHL12_1 DEG_Kelch_KLHL3_1 DEG_MDM2_SWIB_1 DEG_Nend_Nbox_1 DEG_Nend_UBRbox_1 DEG_Nend_UBRbox_2 DEG_Nend_UBRbox_3 DEG_Nend_UBRbox_4 DEG_ODPH_VHL_1 DEG_SCF_FBW7_1 DEG_SCF_FBW7_2 DEG_SCF_FBXO31_1 DEG_SCF_SKP2-CKS1_1 DEG_SCF_TRCP1_1 DEG_SIAH_1 DOC_AGCK_PIF_1 DOC_AGCK_PIF_2 DOC_AGCK_PIF_3 DOC_ANK_TNKS_1 DOC_CDC14_PxL_1 DOC_CKS1_1 DOC_CYCLIN_D_Helix_1 DOC_CYCLIN_RevRxL_6 DOC_CYCLIN_RxL_1 DOC_CYCLIN_yClb1_LxF_4 DOC_CYCLIN_yClb3_PxF_3 DOC_CYCLIN_yCln2_LP_2 DOC_GSK3_Axin_1 DOC_MAPK_DCC_7 DOC_MAPK_FxFP_2 DOC_MAPK_gen_1 DOC_MAPK_GRA24_9 DOC_MAPK_HePTP_8 DOC_MAPK_JIP1_4 DOC_MAPK_MEF2A_6 DOC_MAPK_NFAT4_5 DOC_MAPK_RevD_3 DOC_MIT_MIM_1 DOC_PP1_MyPhoNE_1 DOC_PP1_RVXF_1 DOC_PP1_SILK_1 DOC_PP2A_B56_1 DOC_PP2A_KARD_1 DOC_PP2B_LxvP_1 DOC_PP2B_PxIxIT_1 DOC_PUB_PIM_1 DOC_RSK_DDVF_1 DOC_SPAK_OSR1_1 DOC_TBK1_STING_1 DOC_WD40_RPTOR_TOS_1 DOC_WW_Pin1_4 LIG_14-3-3_CanoR_1 LIG_14-3-3_ChREBP_3 LIG_14-3-3_CterR_2 LIG_ActinCP_CPI_1 LIG_ActinCP_TwfCPI_2 LIG_Actin_RPEL_3 LIG_Actin_WH2_1 LIG_Actin_WH2_2 LIG_ANK_PxLPxL_1 LIG_AP2alpha_1 LIG_AP2alpha_2 LIG_APCC_ABBA_1 LIG_APCC_Cbox_1 LIG_APCC_Cbox_2 LIG_AP_GAE_1 LIG_Arc_Nlobe_1 LIG_ARL_BART_1 LIG_BH_BH3_1 LIG_BIR_II_1 LIG_BIR_III_1 LIG_BIR_III_2 LIG_BIR_III_3 LIG_BIR_III_4 LIG_CaM_1-14-15-16_REV_1 LIG_CaM_1-26_7 LIG_CaM_1-5-10-14_3 LIG_CaM_1-8-14_4 LIG_CaM_1-8-9-10_5 LIG_CaM_1-8_REV_2 LIG_CaM_IQ_9 LIG_CaMK_CASK_1 LIG_CaM_NSCaTE_8 LIG_CAP-Gly_1 LIG_CAP-Gly_2 LIG_Clathr_ClatBox_1 LIG_Clathr_ClatBox_2 LIG_CNOT1_NIM_1 LIG_CSK_EPIYA_1 LIG_CtBP_PxDLS_1 LIG_deltaCOP1_diTrp_1 LIG_DLG_GKlike_1 LIG_Dynein_DLC8_1 LIG_EABR_CEP55_1 LIG_EF_ALG2_ABM_1 LIG_EF_ALG2_ABM_2 LIG_EH_1 LIG_eIF4E_1 LIG_eIF4E_2 LIG_EVH1_1 LIG_EVH1_2 LIG_EVH1_3 LIG_FAT_LD_1 LIG_FERM_MyoX_1 LIG_FZD_DVL_PDZ LIG_G3BP_FGDF_1 LIG_GBD_Chelix_1 LIG_GBD_WASP_1 LIG_GSK3_LRP6_1 LIG_GYF LIG_IBAR_NPY_1 LIG_IRF7_LxLS_2 LIG_IRFs_LxIS_1 LIG_KLC1_WD_1 LIG_KLC1_Yacidic_2 LIG_LIR_Apic_2 LIG_LIR_Gen_1 LIG_LIR_LC3C_4 LIG_LIR_Nem_3 LIG_LYPXL_L_2 LIG_LYPXL_S_1 LIG_LYPXL_yS_3 LIG_MYND_3 LIG_OCRL_FandH_1 LIG_PAM2_1 LIG_PAM2_2 LIG_PDZ_Class_1 LIG_PDZ_Class_2 LIG_PDZ_Class_3 LIG_PDZ_Wminus1_1 LIG_Pex14_1 LIG_Pex14_2 LIG_Pex14_3 LIG_Pex14_4 LIG_Pex3_1 LIG_PIP2_ANTH_1 LIG_PIP2_ENTH_1 LIG_PROFILIN_1 LIG_PTAP_UEV_1 LIG_PTB_Apo_2 LIG_PTB_Phospho_1 LIG_SH2_CRK LIG_SH2_GRB2like LIG_SH2_NCK_1 LIG_SH2_PTP2 LIG_SH2_SFK_2 LIG_SH2_SFK_CTail_3 LIG_SH2_STAT3 LIG_SH2_STAT5 LIG_SH2_STAT6 LIG_SH3_1 LIG_SH3_2 LIG_SH3_3 LIG_SH3_4 LIG_SH3_CIN85_PxpxPR_1 LIG_SH3_PxRPPK_7 LIG_SH3_PxxDY_5 LIG_SH3_PxxPPRxxK_8 LIG_SH3_PxxxRxxKP_6 LIG_SPRY_1 LIG_SUFU_1 LIG_SxIP_EBH_1 LIG_TPR LIG_TRAF2like_MATH_loPxQ_2 LIG_TRAF2like_MATH_shPxQ_1 LIG_TRAF3_MATH_PxP_3 LIG_TRAF4_MATH_1 LIG_TRAF6_MATH_1 LIG_TYR_ITAM LIG_TYR_ITIM LIG_TYR_ITSM LIG_UFM1_UFIM_1 LIG_VCP_SHPBox_1 LIG_VCP_VBM_3 LIG_VCP_VIM_2 LIG_Vh1_VBS_1 LIG_WH1 LIG_WRC_WIRS_1 LIG_WW_1 LIG_WW_2 LIG_WW_3 MOD_AAK1BIKe_LxxQxTG_1 MOD_CDC14_SPxK_1 MOD_CDK_SPK_2 MOD_CDK_SPxK_1 MOD_CDK_SPxxK_3 MOD_CK1_1 MOD_CK2_1 MOD_DYRK1A_RPxSP_1 MOD_GSK3_1 MOD_LATS_1 MOD_LOK_YxT_1 MOD_NEK2_1 MOD_NEK2_2 MOD_NMyristoyl MOD_PIKK_1 MOD_PK_1 MOD_PKA_1 MOD_PKA_2 MOD_PKB_1 MOD_PLK MOD_Plk_1 MOD_Plk_2-3 MOD_Plk_4 MOD_PRMT_GGRGG_1 MOD_ProDKin_1 MOD_SPalmitoyl_2 MOD_SPalmitoyl_4 MOD_TYR_CSK MOD_TYR_DYR ELM:old_LIG_14-3-3_1 ELM:old_LIG_14-3-3_2 ELM:old_LIG_14-3-3_3 TRG_AP2beta_CARGO_1 TRG_Cilium_Arf4_1 TRG_Cilium_RVxP_2 TRG_DiLeu_BaEn_1 TRG_DiLeu_BaEn_2 TRG_DiLeu_BaEn_3 TRG_DiLeu_BaEn_4 TRG_DiLeu_BaLyEn_6 TRG_DiLeu_LyEn_5 TRG_ENDOCYTIC_2 TRG_ER_diArg_1 TRG_ER_diLys_1 TRG_ER_FFAT_1 TRG_ER_FFAT_2 TRG_Golgi_diPhe_1 TRG_LysEnd_APsAcLL_1 TRG_LysEnd_APsAcLL_3 TRG_LysEnd_GGAAcLL_1 TRG_LysEnd_GGAAcLL_2 TRG_NES_CRM1_1 TRG_NESrev_CRM1_2 TRG_PTS1 TRG_PTS2 )
Molecular Function:
Protein Farnesyltransferase (also annotated in class: )
Protein Geranylgeranyltransferase (also annotated in class: )
Protein Prenyltransferase (also annotated in class: )

o 17 Instances for MOD_CAAXbox
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)

Acc., Gene-, Name	Start	End	Subsequence	Logic	#Ev.	Organism	Notes
Q5WSS0 lpl2806 Q5WSS0_LEGPL	526	529	SDAVRQSPGDEHKNNACVIS	TP	2	Legionella pneumophila str. Lens
Q5ZSJ2 lpg2525 Q5ZSJ2_LEGPH	441	444	TIELFNKYTEEKTNNFCSIL	TP	2	Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q56061 sifA SIFA_SALTY	333	336	QLTTLHVRSEQQSGCLCCFL	TP	5	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Q5ZSH6 lpg2541 Q5ZSH6_LEGPH	274	277	KQRKDTNNYKDTKKHRCTIM	TP	3	Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZSZ1 lpg2375 Q5ZSZ1_LEGPH	154	157	LHGEPEMTYKPKFTEQCSIL	TP	3	Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5WTP6 lpl2477 Q5WTP6_LEGPL	196	199	FYNSDSDSDTSDPDPKCTIM	TP	3	Legionella pneumophila str. Lens
Q5ZYV7 lpg0254 Q5ZYV7_LEGPH	186	189	QEYSRLRWKPPEKESVCVLM	TP	2	Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q5ZTL7 legAU13 Q5ZTL7_LEGPH	169	172	RALIRGMQEEKIAQSKCLVC	TP	5	Legionella pneumophila subsp. pneumophila str. Philadelphia 1
P01115 H-RAS RASH_MSVHA	238	241	KLNPPDESGPGCMSCKCVLS	TP	2	Harvey murine sarcoma virus
P34165 MFA1 MFA1_YEAST	33	36	EKKDNYIIKGVFWDPACVIA	TP	1	Saccharomyces cerevisiae S288c
P01116-2 KRAS RASK_HUMAN	185	188	KMSKDGKKKKKKSKTKCVIM	TP	3	Homo sapiens (Human)	1D8D 1D8D
P01116 KRAS RASK_HUMAN	186	189	KISKEEKTPGCVKIKKCIIM	TP	1	Homo sapiens (Human)
P01111 NRAS RASN_HUMAN	186	189	KLNSSDDGTQGCMGLPCVVM	TP	2	Homo sapiens (Human)
P01112 HRAS RASH_HUMAN	186	189	KLNPPDESGPGCMSCKCVLS	TP	4	Homo sapiens (Human)
P20700 LMNB1 LMNB1_HUMAN	583	586	EELFHQQGTPRASNRSCAIM	TP	3	Homo sapiens (Human)
Q8CFN2 Cdc42 CDC42_RAT	188	191	AILAALEPPEPKKSRRCVLL	TP	1	Rattus norvegicus (Norway rat)	1TNZ 1TNZ
P60953 CDC42 CDC42_HUMAN	188	191	AILAALEPPEPKKSRRCVLL	TP	2	Homo sapiens (Human)	1

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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