ELM - instance MOD_CAAXbox in sequence P60953 at position 188

ELM

The Eukaryotic Linear Motif resource for

Functional Sites in Proteins

o Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002604	P60953 CDC42 CDC42_HUMAN	188	191	AILAALEPPEPKKSRRCVLL	TP	---	Homo sapiens (Human)	191

o Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:1003	geranylgeranylase assay	Wilson,1998	support	certain	InteractionDetection
experimental	MI:0586	inhibitor	Wilson,1998	support	certain

o Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000548:
ELM Switch SWTI000548
Alternative splicing removes the prenylation motif of Cell division control protein 42 homolog (CDC42), abrogating binding to Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA). The canonical, prenylated Cdc42 isoform (Cdc42-pren or Isoform Placental) is expressed in all tissues, the variant, palmitoylated form (Cdc42-palm or Isoform Brain) is expressed only in brain.

o Pathways

KEGG: The sequence P60953 is implicated in the following 31 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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