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Direct activation of protein kinases by unanchored polyubiquitin chains Show undefined attributes

author

[Person:202467] Xia, ZP
[Person:201393] Sun, L
[Person:433943] Chen, X
[Person:434117] Pineda, G
[Person:390901] Jiang, X
[Person:202518] Adhikari, A
[Person:217223] Zeng, W
[Person:202464] Chen, ZJ

created [InstanceEdit:434122] Shamovsky, V, 2009年08月26日

dbId 434128

displayName Direct activation of protein kinases by unanchored polyubiquitin chains

journal Nature

pubMedIdentifier 19675569

schemaClass LiteratureReference

title Direct activation of protein kinases by unanchored polyubiquitin chains

url http://www.ncbi.nlm.nih.gov/pubmed/19675569

year 2009

Referrals

(literatureReference)

[Reaction:R-GGA-573296] Activated TRAF6 recruits TAK1 kinase complex upon TLR7 or TLR21 stimulation
[BlackBoxEvent:R-GGA-573294] Activated TRAF6 synthesizes free K63 linked pUb chains
[BlackBoxEvent:R-GGA-1227893] TRAF3/or TRAF6 ubiquitination within dsRNA:MDA5:IPS1:TRAF3/TRAF6 complex
[Summation:433904] Together with ubiquitin-conjugating E2-type enzymes UBC13 an...
[Pathway:R-HSA-9014325] TICAM1,TRAF6-dependent induction of TAK1 complex
[Reaction:R-HSA-975097] Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
[Summation:2685555] Binding of TAB2 and TAB3 to K63-linked polyubiquitin chains ...
[Pathway:R-HSA-937072] TRAF6-mediated induction of TAK1 complex within TLR4 complex
[Reaction:R-GGA-433950] TRAF6 recruits TAK1 kinase complex
[BlackBoxEvent:R-GGA-433936] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex dsRNA :TLR3 :TICAM1
[Polymerisation:R-HSA-450358] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation
[Reaction:R-GGA-451463] pUb_TRAF6 pIRAK2 recruits TAK1 kinase complex
[Summation:446233] TRAF6 generates unanchored Lys63-linked polyubiquitin chains...
[BlackBoxEvent:R-GGA-451470] Activated chicken TRAF6 synthesizes free K63bound poly_Ub chains within the complex p-IRAK2:pUb_oligo TRAF6
[Reaction:R-HSA-936947] Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
[Summation:450280] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
[Reaction:R-HSA-177690] Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
[Summation:9628446] E3 ubiquitin ligase TRAF6 generates free K63 -linked polyubi...
[Polymerisation:R-HSA-9628444] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
[Summation:450304] TRAF6 possesses ubiquitin ligase activity and undergoes K-63...
[Summation:9645505] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
[Reaction:R-HSA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
[Summation:9645510] E3 ubiquitin ligase TRAF6 generates free K63 -linked polyubi...
[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
[Summation:447018] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
[Reaction:R-HSA-936960] Activated TRAF6:p-IRAK2 interacts with TAK1 complex
[Summation:450260] Polyubiquitinated TRAF6 (as E3 ubiquitin ligase) generates f...
[Polymerisation:R-HSA-936986] Activated TRAF6 synthesizes unanchored polyubiquitin chains

(author)

[Person:202518] Adhikari, A
[Person:217223] Zeng, W
[Person:202464] Chen, ZJ
[Person:434117] Pineda, G
[Person:201393] Sun, L
[Person:433943] Chen, X
[Person:390901] Jiang, X
[Person:202467] Xia, ZP

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