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Reaction
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Entries
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
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authored
[InstanceEdit:9645656] Shamovsky, Veronica, 2019年05月17日
category
binding
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9645472] Shamovsky, Veronica, 2019年05月12日
dbId
9645406
displayName
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
edited
[InstanceEdit:9657757] Shamovsky, Veronica, 2019年08月09日
eventOf
[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
followingEvent
[Reaction:R-HSA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex - Homo sapiens
input
[Complex:R-HSA-9645508] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol]
2 ×
[Polymer:R-HSA-450152] K63polyUb [cytosol]
2 ×
[Complex:R-HSA-450277] TAB1:TAB2,TAB3:TAK1 [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
[LiteratureReference:208226] TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
[LiteratureReference:202523] Ubiquitin-mediated activation of TAK1 and IKK
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
orthologousEvent
[Reaction:R-GGA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Gallus gallus
[Reaction:R-XTR-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Xenopus tropicalis
[Reaction:R-SSC-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Sus scrofa
[Reaction:R-BTA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Bos taurus
[Reaction:R-CFA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Canis familiaris
[Reaction:R-RNO-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Rattus norvegicus
[Reaction:R-MMU-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Mus musculus
output
[Complex:R-HSA-9645445] ALPK1:ADP-heptose:p-T9-TIFA:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [cytosol]
precedingEvent
[Polymerisation:R-HSA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Homo sapiens
releaseDate
2019年09月10日
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9647756] Gillespie, Marc E, 2019年06月03日
[InstanceEdit:9652842] Shao, Feng, 2019年07月08日
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-9645406
summation
[Summation:9645505] TAK1-binding protein 2 (TAB2) and/or TAB3, as part of a comp...
Referrals
(hasEvent)
[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)
[Reaction:R-HSA-9645442] Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
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