Reactome Pathway Database
Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Reactome Pathway Database
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Schema
>
Polymerisation
>
Entries
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
Show undefined attributes
Go to Details
authored
[InstanceEdit:9645656] Shamovsky, Veronica, 2019年05月17日
catalystActivity
[CatalystActivity:9645480] ubiquitin-protein transferase activity of ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63-linked pUb-TRAF6 oligomer [cytosol]
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:9645472] Shamovsky, Veronica, 2019年05月12日
dbId
9645394
displayName
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
edited
[InstanceEdit:9657757] Shamovsky, Veronica, 2019年08月09日
eventOf
[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway - Homo sapiens
followingEvent
[Reaction:R-HSA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1) - Homo sapiens
input
[DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:434128] Direct activation of protein kinases by unanchored polyubiquitin chains
maxDepth
1
modified
[InstanceEdit:10680101] Weiser, Joel, 2025年08月27日
name
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation
orthologousEvent
[Polymerisation:R-GGA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Gallus gallus
[Polymerisation:R-XTR-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Xenopus tropicalis
[Polymerisation:R-SSC-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Sus scrofa
[Polymerisation:R-BTA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Bos taurus
[Polymerisation:R-CFA-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Canis familiaris
[Polymerisation:R-RNO-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Rattus norvegicus
[Polymerisation:R-MMU-9645394] Activated TRAF6 synthesizes unanchored polyubiquitin chains upon ALPK1:ADP-heptose stimulation - Mus musculus
output
[Polymer:R-HSA-450152] K63polyUb [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-9645414] Auto ubiquitination of TRAF6 bound to ALPK1:ADP-heptose:TIFA oligomer - Homo sapiens
releaseDate
2019年09月10日
requiredInputComponent
[EntityWithAccessionedSequence:R-HSA-174100] UBE2E1 [cytosol] - Homo sapiens
[Complex:R-HSA-202463] UBE2N:UBE2V1 [cytosol] - Homo sapiens
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9647756] Gillespie, Marc E, 2019年06月03日
[InstanceEdit:9652842] Shao, Feng, 2019年07月08日
schemaClass
Polymerisation
species
[Species:48887] Homo sapiens
stId
R-HSA-9645394
summation
[Summation:9645510] E3 ubiquitin ligase TRAF6 generates free K63 -linked polyubi...
Referrals
(hasEvent)
[Pathway:R-HSA-9645460] Alpha-protein kinase 1 signaling pathway
(precedingEvent)
[Reaction:R-HSA-9645406] ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
Download
Close
AltStyle
によって変換されたページ
(->オリジナル)
/
アドレス:
モード:
デフォルト
音声ブラウザ
ルビ付き
配色反転
文字拡大
モバイル